Successive cartridge clean-up method for the simultaneous determination of matrine and oxymatrine in biopesticides containing Sophora flavescens extract was developed and validated by UPLC. The clean-up method was established with ENVI-Carb (0.5 g) and C18 SPE (0.5 g) cartridges for the bioactive alkaloid in biopesticides from S. flavescens, and the eluate was analyzed to quantify the matrine and oxymatrine by UPLC. The developed method was validated, and the recovery and LOQ of both materials were 105.0% and 103.6%, and 0.050 and 0.684 mg·kg −1 , respectively. Of the twenty one samples, the total content of matrines were analyzed by using the developed method and the result showed
Background:
Two-stage ossiculoplasty has been widely used for hearing improvement in chronic otitis media with or without cholesteatoma. However, the outcomes of single-stage ossiculoplasty have not been fully clarified.The aim of this study is to determine whether the outcomes of single-stage ossiculoplasty are comparable with those of 2-stage ossiculoplasty in chronic otitis media with or without cholesteatoma.
Methods:
Medical records of 191 cases (187 patients) who underwent single-stage ossiculoplasty from January 2011 to May 2018 at our hospital were retrospectively reviewed.
Results:
Polycel and titanium were used in 56 and 135 cases, respectively. In chronic otitis media without cholesteatoma, the success rate of polycel and titanium partial ossicular replacement prosthesis was 80.7% and 81.6%, respectively. In chronic otitis media with cholesteatoma, the success rate of polycel and titanium partial ossicular replacement prosthesis was 63.6% and 64.6%, respectively, while that of polycel and titanium total ossicular replacement prosthesis was 45.9% and 47.8%, respectively.
Conclusion:
These results suggest that single-stage ossiculoplasty is a suitable option for recovering postoperative hearing in chronic otitis media with or without cholesteatoma. Thus, if middle ear inflammation can be sufficiently treated in the first stage, single-stage ossiculoplasty is a suitable option for chronic otitis media with or without cholesteatoma.
As medical images are created, displayed, transmitted or stored in a digital form, there has been a growing interest in protecting the medical images against external/internal attackers. In this paper, we propose a Dual Watermarking Method(DWM) to protect medical images in transmission/storage. As the proposed DWM provides both robustness and fragileness with the embedded watermarks, it can guarantee the integrity of the medical image transmitted and/or stored. In DWM, watermarks are carefully embedded avoiding the areas of Region of Interest(ROI) and the edge of the contents to protect the integrity of the medical image.Based on experimental results, we confirm that our DWM can detect the robust watermark accurately and detect the intentional/unintentional leakage of the transmitted or stored medical image.
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