Hydraulic fracturing tests on Pocheon granite cylinders at seven different injection rates varying from 1 to 100 mm 3 /s were conducted. They were compared with sleeve fracturing tests in which borehole was sleeved, and therefore, water infiltration influence was excluded. Hydraulic fracturing behavior of granite is significantly influenced by water infiltration, which is closely related to the preexisting microcracks in granite as well as the cleavage anisotropy. There was a threshold injection rate to fracture the granite specimen under given stress conditions. When the injection rate is below the threshold, water infiltrated granite matrix with slow increment of injection pressure, and the specimen finally reached a full saturation without fracturing. Injection pressure developed nonlinearly with time during water infiltration, while approximately linearly when infiltration was excluded. For both hydraulic and sleeve fracturing tests, breakdown pressure increases with increasing injection rate. The breakdown pressures by sleeve fracturing were more than two times higher than those in hydraulic fracturing. X-ray computed tomography (CT) observations show that induced fractures are along the weaker cleavage parallel to the direction of the vertical stress. The higher breakdown pressure results in a larger aperture of fractures in hydraulic fracturing tests.

AIMTo evaluate the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) in patients with colorectal cancer (CRC).METHODSBetween April 1996 and December 2010, medical records from a total of 1868 patients with CRC were retrospectively reviewed. The values of simple inflammatory markers including NLR and PLR in predicting the long-term outcomes of these patients were evaluated using Kaplan-Meier curves and Cox regression models.RESULTSThe median follow-up duration was 46 mo (interquartile range, 22-73). The estimation of NLR and PLR was based on the time of diagnosis. In multivariate Cox regression analysis, high NLR (≥ 3.0) and high PLR (≥ 160) were independent risk factors predicting poor long-term outcomes in patients with stage III and IV CRC. However, high NLR and high PLR were not prognostic factors in patients with stage I and II CRC.CONCLUSIONIn this study, we identified that high NLR (≥ 3.0) and high PLR (≥ 160) are useful prognostic factors to predict long-term outcomes in patients with stage III and IV CRC.

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Laboratory hydraulic fracturing tests on cubic granite specimens with a side length of 100 mm were performed under true triaxial stress conditions combined with acoustic emission monitoring. Six different injection schemes were applied to investigate the influence of the injection scheme on hydraulic performance and induced seismicity during hydraulic fracturing. Three of these schemes are injection rate controlled: constant rate continuous injection (CCI), stepwise rate continuous injection (SCI), and cyclic progressive injection (CPI); the other three are pressurization rate controlled: stepwise pressurization (SP), stepwise pulse pressurization (SPP) and cyclic pulse pressurization (CPP). The test results show that the SPP scheme achieves the highest increase in injectivity among the six schemes. The CPI scheme generates the lowest induced seismicity while the improvement in injectivity is the least pronounced. The CPP scheme allows increasing injectivity and decreasing induced seismicity, and is suggested as a promising alternative injection scheme for field applications. Thin section microscopic observations of fractured specimens show that intragranular fractures splitting microcline, orthoclase and quartz grains dominate the hydraulic fractures independent of the injection scheme. The SPP scheme creates the largest fracture length, which explains the highest injectivity value among all schemes. Tests with relatively low magnitude of maximum AE amplitude correspond to short fracture length and small portions of intragranular fractures in microcline grains. Quartz grains are more fractured than microcline and orthoclase grains, and quartz chips (natural proppants) are frequently observed adjacent to hydraulic fractures. The laboratory test results show the potential for hydraulic fracture growth control in field applications by advanced fluid injection schemes, i.e. cyclic pulse pressurization of granitic rock mass.

This chapter introduces laboratory studies on the hydraulic fracturing of granite cores. Some of the most important factors influencing fracturing are considered, including injection rate, fluid infiltration, fluid viscosity, borehole size, and injection scheme. Results from acoustic emission monitoring help elucidate the fracturing process. Hydraulic fractures of granite samples are observed and analysed at the mineral scale with the aid of X-ray scanning and Computed Tomography. A first attempt to investigate the initiation and propagation of hydraulic fractures in granite drill cores during cyclic injection is presented.

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The purpose of this study is to investigate the influence of cleavages on indirect tensile strength (ITS) of the granite. Brazilian disc tests and ring tests with three different hole sizes were performed. 2D DEM (Discrete Element Method) simulation was employed to further understand the failure process during the tests and the mechanism behind. Results show that ITS decreases across hardway, grain and rift cleavage. Measured average ITS from ring tests is about 2.5~6.4 times of those measured from Brazilian disc tests, and it decreases with increasing ratio of diameters of inner hole and specimen. Failure pattern in ring tests is influenced by both hole size and relative positions of cleavages parallel and perpendicular to the loading direction.

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