IMPORTANCE Data on P2Y12 inhibitor monotherapy after short-duration dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary intervention are limited. OBJECTIVE To determine whether P2Y12 inhibitor monotherapy after 3 months of DAPT is noninferior to 12 months of DAPT in patients undergoing PCI. DESIGN, SETTING, AND PARTICIPANTS The SMART-CHOICE trial was an open-label, noninferiority, randomized study that was conducted in 33 hospitals in Korea and included 2993 patients undergoing PCI with drug-eluting stents. Enrollment began March 18, 2014, and follow-up was completed July 19, 2018. INTERVENTIONS Patients were randomly assigned to receive aspirin plus a P2Y12 inhibitor for 3 months and thereafter P2Y12 inhibitor alone (n = 1495) or DAPT for 12 months (n = 1498). MAIN OUTCOMES AND MEASURES The primary end point was major adverse cardiac and cerebrovascular events (a composite of all-cause death, myocardial infarction, or stroke) at 12 months after the index procedure. Secondary end points included the components of the primary end point and bleeding defined as Bleeding Academic Research Consortium type 2 to 5. The noninferiority margin was 1.8%. RESULTS Among 2993 patients who were randomized (mean age, 64 years; 795 women [26.6%]), 2912 (97.3%) completed the trial. Adherence to the study protocol was 79.3% of the P2Y12 inhibitor monotherapy group and 95.2% of the DAPT group. At 12 months, major adverse cardiac and cerebrovascular events occurred in 42 patients in the P2Y12 inhibitor monotherapy group and in 36 patients in the DAPT group (2.9% vs 2.5%; difference, 0.4% [1-sided 95% CI,-ϱ% to 1.3%]; P = .007 for noninferiority). There were no significant differences in all-cause death (21 [1.4%] vs 18 [1.2%]; hazard ratio [HR], 1.18; 95% CI, 0.63-2.21; P = .61), myocardial infarction (11 [0.8%] vs 17 [1.2%]; HR, 0.66; 95% CI, 0.31-1.40; P = .28), or stroke (11 [0.8%] vs 5 [0.3%]; HR, 2.23; 95% CI, 0.78-6.43; P = .14) between the 2 groups. The rate of bleeding was significantly lower in the P2Y12 inhibitor monotherapy group than in the DAPT group (2.0% vs 3.4%; HR, 0.58; 95% CI, 0.36-0.92; P = .02). CONCLUSIONS AND RELEVANCE Among patients undergoing percutaneous coronary intervention, P2Y12 inhibitor monotherapy after 3 months of DAPT compared with prolonged DAPT resulted in noninferior rates of major adverse cardiac and cerebrovascular events. Because of limitations in the study population and adherence, further research is needed in other populations.

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Conventional computing systems have been able to be integrated into daily objects and connected to each other due to advances in computing and network technologies, such as wireless sensor networks (WSNs), forming a global network infrastructure, called the Internet of Things (IoT). To support the interconnection and interoperability between heterogeneous IoT systems, the availability of standardized, open application programming interfaces (APIs) is one of the key features of common software platforms for IoT devices, gateways, and servers. In this paper, we present a standardized way of extending previously-existing WSNs towards IoT systems, building the world of the Web of Things (WoT). Based on the oneM2M software platforms developed in the previous project, we introduce a well-designed open API scheme and device-specific thing adaptation software (TAS) enabling WSN elements, such as a wireless sensor node, to be accessed in a standardized way on a global scale. Three pilot services are implemented (i.e., a WiFi-enabled smart flowerpot, voice-based control for ZigBee-connected home appliances, and WiFi-connected AR.Drone control) to demonstrate the practical usability of the open API scheme and TAS modules. Full details on the method of integrating WSN elements into three example systems are described at the programming code level, which is expected to help future researchers in integrating their WSN systems in IoT platforms, such as oneM2M. We hope that the flexibly-deployable, easily-reusable common open API scheme and TAS-based integration method working with the oneM2M platforms will help the conventional WSNs in diverse industries evolve into the emerging WoT solutions.

The Internet of Things allows things in the world to be connected to each other and enables them to automate daily tasks without human intervention, eventually building smart spaces. This article demonstrates a prototype service based on the Internet of Things, TTEO (Things Talk to Each Other). We present the full details on the system architecture and the software platforms for IoT servers and devices, called Mobius and &Cube, respectively, complying with the globally-applicable IoT standards, oneM2M, a unique identification scheme for a huge number of IoT devices, and service scenarios with an intuitive smartphone app. We hope that our approach will help developers and lead users for IoT devices and application services to establish an emerging IoT ecosystem, just like the ecosystem for smartphones and mobile applications.

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In the past decades, the unmanned aerial systems have been utilized only for military operations. However, recently, the potential uses and applicability of unmanned aerial vehicles (commonly known as drones) in civilian application domains are becoming a fast-growing phenomenon. A flying ad hoc network is a wireless ad hoc network specifically designed for the communication of unmanned aerial vehicles. Multicast routing is one of the vital aspects in wireless ad hoc networks. Using multicast transmission approaches, flying ad hoc network applications may need to send the same message to a specific group of flying nodes. The multicast communication approaches can benefit flying ad hoc network applications in conserving the scarce resources of flying nodes. Research works have been proposed to tackle the challenges in multicast routing with multi-hop communication in ad hoc network environments. Nevertheless, the conventional multicast routing mechanisms incur excessive control message overhead when a large number of nodes experience frequent topological changes. A scalable geographic multicast routing mechanism, which specially require localized operation and reduced control packet overhead, is necessary. Multicast routing in flying ad hoc networks is extremely challenging because of the dynamic topology changes and network disconnection resulted from frequent mobility of nodes. In this article, we present and implement a scalable and predictive geographic multicast routing mechanism in flying ad hoc networks. In uniform and random deployment scenarios, the MATLAB-based evaluation result has revealed that when the communication range increases, the probability of finding one-hop predicted forwarders to reach multicast destinations also increases. The implementation of scalable and predictive geographic multicast routing mechanism in flying ad hoc network is done using Optimizing Network Engineering Tools Modeler 16.0. We have added the scalable and predictive geographic multicast routing mechanism in flying ad hoc network as a new routing scheme in the Mobile Ad hoc Network routing protocol groups of the Optimizing Network Engineering Tools Modeler. Then, the performance of scalable and predictive geographic multicast routing mechanism in flying ad hoc network is compared with two of the existing Mobile Ad hoc Network routing protocols (Geographic Routing Protocol and Dynamic Source Routing). Eventually, we present two instance scenarios regarding the integration of scalable and predictive geographic multicast routing mechanism in flying ad hoc network scheme in the Internet of Things platform.

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