Juvenile fibroadenoma comprises about 4% of the total fibroadenomas. The incidence of giant juvenile fibroadenomas is merely 0.5% of all the fibroadenomas. Bilateral giant juvenile fibroadenomas are extremely rare. We are presenting a case of giant juvenile fibroadenomas in an 11-year-old pre-pubertal girl. The diagnosis was made on fine-needle aspiration cytology which was confirmed on histopathology. As these tumors are mostly benign, breast-conserving surgery is done so that patient can lead a normal life without psychological trauma.
Keloid disease is a fibro proliferative skin tumor and occurs after a skin trauma in genetically vulnerable individuals. Etiology of keloid is unclear. Causative factors for keloid are increased familial aggregation, a higher prevalence in certain races, parallelism in identical twins, and alteration in gene expression. It appears that the surroundings activate the disease in genetically susceptible individuals. Several genes are considered responsible for keloid disease, but no single gene mutation has thus far been found to be responsible. Therefore, we should apply a combination of methods such as association, gene-gene interaction, epigenetics, linkage, gene expression, and protein analysis to find out the keloid etiology. Incidence of familial keloid is common in Africans but is uncommon in Indian population. It may be due to autosomal dominant or autosomal recessive inheritance.
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