The main aim of our study was to perform the epidemiological analysis of the breast cancer in Autonomous Province of Vojvodina, Republic of Serbia, in 15 years period (1987-2001). Descriptive method was used in epidemiological analysis of the data from the Vojvodina cancer registry. According to our results the breast cancer is the most frequent neoplasm in women in Vojvodina (26.54% of all cancers), and the leading cause of mortality (20.97%). Linear trend for both incidence and mortality crude and standardized rates showed the significant and unfavorable increase from 1987 to 2001.
Future treatment strategies in preclinical and clinical investigations are directed towards new dosing schedules of existing drugs, new genetic and epigenetic targets and combination of different agents, including hypomethylation agents and histone deacetylase inhibitors.
During the recent genomics and proteomics era, high-resolution, genome-wide approaches have revealed numerous promising new drug targets and disease biomarkers, accelerating and emphasizing the need for targeted molecular therapy compounds. Significant progress has been made in understanding the pathogenesis of hematological malignancies there by, revealing new drug targets. Introduction of multiple new technologies in cancer research have significantly improved the drug discovery process, leading to key success in targeted cancer therapeutics, including tyrosine kinase inhibitors. The studies of receptor tyrosine kinases and their role in malignant transformation are already translated from the preclinical level (cell-based and animal models) to clinical studies, enabling the more complete understanding of tumor cell biology and improvement of tumor therapy.
UvodBrojna istraživanja tokom poslednje decenije ukazuju na značaj uloge vitamina D u prevenciji i povoljnom efektu na sprečavanje i odlaganje razvoja brojnih hroničnih bolesti, a posebno multiple skleroze, i u slučaju deficijencije ukazuju na potrebu za korekcijom unosa dnevnih doza vitamina D i njegovom adekvatnom suplementacijom.Sprovedeno istraživanje predstavlja pregled brojnih istraživanja, meta-analiza, randomiziranih studija i drugih naučnih dokaza o uticaju vitamina D na prevenciju nastanka multiple skleroze, unapređenje opšteg stanja obolelih i na ishod bolesti. Obuhvaćena su istraživanja tokom perioda 2007-2017. uvidom u bazu podataka MEDLINE, kombinovanjem termina multipla skleroza, vitamin D i suplementacija.
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