Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 -related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation.
Background Periodontitis is a high prevalence disease, affecting up to 80% of the world's population. Recently studies have shown a connection between periodontal disease and cardiovascular disease, as oxidative stress plays an important role in chronic inflammatory diseases such as periodontal disease and cardiovascular disease. Nuclear factor erythroid 2 - related factor 2 (Nrf2) is the core transcriptional regulator of endogenous antioxidant system and plays a cellular defense role in antioxidant, anti-inflammatory and immune response. Objective To explore Nrf2/antioxidant responsive element (ARE) signaling pathway in periodontitis or periodontitis complicated with atherosclerosis. Method With "Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2), Periodontitis, Atherosclerosis, Oxidative Stress" as the search terms, the authors searched related articles published during 2016-2021 in PubMed, CNKI, Science Direct and other databases by computer, and made the following review through screening, induction and summary. Result & Conclusion Nrf2/ARE signaling pathway is one of the important mechanisms connecting chronic periodontitis and atherosclerosis. Nrf2 can slow down the occurrence and development of periodontitis by promoting osteoblast differentiation, inhibiting osteoclast activation, regulating mesenchymal stem cell proliferation, differentiation and apoptosis. However, inhibition of Nrf2/ARE signaling pathway may increase the risk of periodontitis with atherosclerosis by destroying the integrity of vascular endothelium, increasing lipid accumulation and promoting inflammation
Objective: Periodontitis is linked to increased prevalence of cardiovascular disease and it is significant to have a comprehensive cognition on the mutual influence for combined treatment. The present investigation aimed to promote oral health instruction to patients with periodontitis and/or cardiovascular disease and the medical staffs from the department of cardiology and stomatology. Materials and Methods: A total of 120 Cardiologist and dentists and 120 patients with cardiovascular diseases were randomly investigated in Hainan public hospitals. The subjects' cognition of the correlation between cardiovascular disease and periodontitis were examined through questionnaires. Results: The public represented by patients with cardiovascular disease in Haikou City has a lack of cognition of the two-way relationship between periodontitis and cardiovascular disease. 32.1% of medical staff and 72.2% of patients did not know that "periodontitis is a cause of cardiovascular disease", and 83.5% of patients did not know that "periodontitis is a complication of cardiovascular disease". 96.3% of dental medical staff and 87.9% of cardiovascular medical staff expressed the willingness to popularize the correlation between the two diseases to patients. Conclusion: The public in Hainan has insufficient understanding of the correlation between periodontitis and cardiovascular diseases. Clinicians should strengthen the education on the bidirectional relationship between periodontitis and cardiovascular disease.
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