A novel 2(2′-hydroxyphenyl) benzothiazole-based cryptand (L) exhibits high fluorescence intensity in the presence of Zn2+ ions by stopping the excited state intramolecular proton transfer (ESIPT) process with a detection limit of 0.20 μM.
A benzothiazole derived chemosensor L has been designed based on the excited-state intramolecular proton transfer (ESIPT) mechanism to afford a fluorescence turn-on response specifically in the presence of Hg(2+) ions over a host of biologically relevant metal ions as well as toxic heavy metal ions. The chemosensor exhibits high sensitivity with the detection limit down to 0.11 μM. The metal binding is supported by (1)H NMR titrations, ESI-MS spectral analysis and substantiated by theoretical calculations using the density functional theory. The probe shows cell membrane permeability and efficiency for the detection of Hg(2+) in HeLa cells.
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