Analogs of vancomycin and pseudo-vancomycin with new sugar attachments in mono-and di-saccharide form have been enzymatically synthesized by glycosylation with overexpressed glycosyltransferases, b1,4-galactosyltransferase and a2,3-sialyl transferases. All four analogs, including galactose-containing derivatives (6 and 8) and galactose-and sialic acid-containing derivatives (7 and 9) were prepared and characterized by HPLC, LC-MS, NMR and MIC test.
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