[reaction: see text] In situ generated allylindium reagents from the reaction of 1 equiv of indium with 1.5 equiv of allyl halides could be effective cross-coupling partners in palladium-catalyzed cross-coupling reactions to aryl halides. The best results were obtained with 2% Pd(2)dba(3)CHCl(3) and 16% Ph(3)P in the presence of 3 equiv of LiCl in DMF at 100 degrees C.
SummaryThe natural amidinomycin ((W, 35)-14) and its three stereoisomers are synthesized from homochual3-oxocyclopentanecarboxytic acids (la) by asymmetric methods, which are based on an asymmetric reductive amination to produce methyl cis-N-( 1 -phenylethyl)-3-aminocyclopentanecarboxylates (3b) via optically active me thy1 N-( l-phenylethyl)-3-iminocyclopmtane-carboxylates (2b) for the cis-isomers of 14. Optically pure trum-3-aminocyclopentane-carboxylic acids (4a) are obtained from the homochiral keto acids la via asymmetric reductive amination of 3-hydroxyiminocyclopentanecarboxytic acids (Sa) and lead to the tmns-isomers of 14.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.