The regulatory guidelines for the research and development of paediatric drugs are still evolving in China. The formulation of the guidelines started from learning and borrowing existing experience, and gradually changed to the exploration and improvement of local guidelines, which was not only in line with international standards but also had breakthroughs, innovations and Chinese characteristics. In this paper, the current setting of paediatric drug research and development in China and corresponding technical guidelines have been introduced from regulatory perspectives, and the accessibility of further improvement in regulatory strategies has also been discussed.

Hetu and luoshu, or the Yellow River trigrams and the Luo River trigrams, also the first mystical images in Chinese graphemic culture, are regarded as the origin of Heluo culture and feature prominently in the history of Chinese culture and Chinese thoughts. Many researchers of different dynasties expounded the sign of the image after the appearance of hetu and luoshu by Chen Tuan. The evolution of hetu and luoshu differed from the general process of symbolic evolution because its significance arose before its image. This particularity is due to the highly comprehensive and highly commensurable nature of hetu and luoshu as a meta-sign. According to the nearly archaeological excavation and using the methodology of "one vigor and four elements", this paper makes the interpretation of its graphic which reflects the wisdom of ancient Chinese philosophy. The interpretation will be analyzed as following: Yin-Yang five-elements, the harmonious relationship between man and nature, meta-sign and the means of image-numerology in Hetu and Luoshu. A thorough study of Hetu and luoshu may help understand the evolution of Chinese nation, Chinese national character, beliefs and orientation of social life, and help clarify the deep historical roots of cultural communication, cultural psychology and spiritual orientation.

Abstract. Hetu and Luoshu, the cultural heritages that reflect ancient Chinese wisdom, are the origins of Heluo culture. The paper will focus on the present study of Hetu and Luoshu and give a prospection of the study trend by combing and analyzing related texts and documentaries.Hetu and Luoshu, or the Yellow River trigrams and the Luo River trigrams, also the first mystical images in Chinese graphemic culture, are regarded as the origin of Heluo culture and feature prominently in the history of Chinese culture and Chinese thoughts. The Legend of Hetu and Luoshu, which was included in the fourth group of National Intangible Cultural Heritage List in 2014, is the fountainhead of Chinese nation and witness the long history of Chinese civilization.