Hyperleukocytosis is defined when the total leukocyte count is more than 100000/cmm. Leukostasis occurs in hyperleukocytic acute myeloid leukemia when the numbers of blasts are very high. Leukostasis causes impaired normal functioning of vascular systems because of crowding of blasts in its microvasculature or in its vessels supplying the nerves. Leukostasis causes early deaths in acute myeloid leukemia (AML) due to involvement of central nervous system and lungs. Acute retention of urine because of haematological causes is rarely seen. Dysfunction of bladder because of leukostasis in hyperleukocytic AML is warning. Cytoreduction therapy in hyperleukocytic AML prevents early deaths.
Abstract:A boy aged 14 years was operated for a cyst in oral cavity. The post-operative stay was complicated by continued bleeding from the site of incision in oral cavity. The bleeding time was found to be normal however coagulation time was found to be 25 minutes. History of any abnormal bleeding in past was not available, parents refused to have noted any swelling in joints. Further evaluation showed abnormally prolonged APTT however PT was normal. Based on mixing experiments and factors assays, diagnosis of factor XI deficiency was made.
Hemophilia due to factor VIII deficiency is most common inherited bleeding disorder in paediatric population. Hemarthrosis is initial manifestation in large number of patients. We are presenting a case of factor X deficiency who presented with knee hemarthrosis.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.