Objective: This study aims that oxidative stress and inflammation status in children and adolescents with attention deficit hyperactivity disorder (ADHD) compared to their healthy peers. Method: Thirty ADHD and healthy controls were included in this study. ADHD diagnosis according to the DSM-V and Conners’ teacher and parent rating scale by a structured psychiatric interview. Total oxidant status (TOS), total antioxidant status (TAS), and total and native thiol levels were determined using photometric methods. Presepsin, Interleukin (IL) 1-ß, IL-6, and Tumor Necrosis Factor-alpha (TNF-α) levels were measured with commercial ELISA kits. Results: We showed that TOS and oxidative stress index were significantly higher in the ADHD group, and TAS was lower than in the control group ( p<.001). Similarly, IL1-ß, IL-6, and TNF-α levels were statistically higher in the ADHD group. Backward LR regression analysis reveals that TOS and IL-6 predicted ADHD. Conclusion: TOS and IL-6 levels may play a role in the pathogenesis of ADHD.
Yaygın eğitim kişilerin toplumsal değişimlere uyumunu sağlamak ve ulusal kalkınma hedeflerine ulaşmak için yaşam boyu eğitim felsefesi çerçevesinde yapılan tüm eğitim faaliyetleridir. Bunlar içinde yaygın din eğitimi resmi olarak Diyanet İşleri Başkanlığı eliyle yürütülen faaliyetlerdir. Özellikle yaygın din eğitimine katılan yetişkinlerin önemli bölümü kadınlardan ve bu eğitimi verenlerin de önemli kısmı kadın Kur'an kursu öğreticilerinden oluşmaktadır. Kur'an kursları aynı zamanda kadınların sosyalleşmesi için de önemli bir görev ifa etmektedir. Yaptığımız bu çalışmada yaygın din eğitimi veren Kur'an kurslarındaki öğreticilerin meslekî doyum düzeyleri ile bunlara etki eden değişkenlerin tespit edilmesi amaçlanmıştır. Çalışma nicel araştırma yöntemine göre yapılmıştır. Bu araştırmada Kuzgun, Sevim ve Hamamcı tarafından geliştirilen Meslekî Doyum Ölçeği kullanılmıştır. 2019 yılında, İstanbul Sancaktepe ve Kartal ilçelerinde çalışan Kur'an kursu öğreticileri araştırma kapsamına alınmıştır. Araştırma sonucunda öğreticilerin meslekî doyum düzeylerinin tam olduğu ortaya çıkmıştır. Kur'an kursu öğreticilerinin tam düzeyde bir mesleki doyum düzeyine sahip olmalarının temel sebeplerinden biri olarak, yapılan işin niteliğinin, manevi yönünün ve toplumdaki itibarının etkisi olduğu söylenebilir. Öğreticilerin doyum düzeylerine etki eden değişkenler arasında medeni durum, eğitim durumu ve sınıflarında okuttukları öğrenci sayıları yer almaktadır. Meslekî gelişim imkânlarına sahip olmanın, öğreticilerin mesleki doyumları üzerinde önemli etkisinin olduğu görülmüştür.
Attention deficit hyperactivity disorder (ADHD) is a childhood-onset disorder that affects 5% to 12% of children worldwide. Etiological factors, including nutrition, are involved in this disease, which is characterized by inattention, impulsivity, and hyperactivity symptoms. Fats, which form an important part of the daily diet, can have effects on ADHD and its symptoms. In the literature, it is stated that omega-3 fatty acids are low in children with ADHD, and supplementation studies may be effective in improving symptoms. In addition, high omega-6/omega-3 fatty acids ratio in the diet and diets rich in saturated and trans fatty acids are associated with ADHD. In this review, the relationship between ADHD and dietary fatty acids will be evaluated.
Objectives: Apigenin and parthenolide as natural products have potent antioxidant and anti-inflammatory outcomes that could make them a perfect option for endometriosis therapy. This study aimed to determine the effects of apigenin and parthenolide on created endometrial implants in a rat model of endometriosis. Methods: Thirty-nine mature, female Sprague-Dawley rats were assigned randomly to six experimental groups four weeks after endometriosis induction. Group 1 (n = 5): Control (CTRL) that opened and closed the abdomen; Group 2 (n = 6): Peritoneal and ovarian endometriosis (POE) + drug-free; Group 3 (n = 7): POE+ Apigenin (APG) (50 mg/kg); Group 4 (n = 7): POE+ Parthenolide (PTL) (10 mg/kg); Group 5 (n = 7): POE+ Apigenin (APG) (50 mg/kg) + Parthenolide (PTL) (10 mg/kg); Group 6 (n = 7): POE+ DMSO. An endometriosis model was created, and histopathological analysis and biochemical evaluation were performed. Serum and peritoneal levels of pro-and-anti-inflammatory cytokine, and oxidative stress of implant tissue were measured. Results: Serum IL-37 levels decreased significantly in the APG-treated group compared to the drug-free group (p = 0.016). The peritoneum and ovary endometriosis histopathologic scores were significantly lower in APG-treated (p = 0.001) and PTL-treated (p = 0.001) groups in comparison to the drug-free group. The oxidative stress index (OSI) values were increased statistically significantly in ovary endometriosis tissue in the drug-free group, (p = 0.001). However, compared to the drug-free group, OSI values decreased statistically significantly in the APG-treated group (p = 0.003). Conclusions: The application of apigenin caused a decrease in oxidative stress and an improvement in histopathological grade. Apigenin may be a novel therapeutic agent for the treatment of endometriosis.
Bu araştırmanın amacı, özel gereksinimli göçmen öğrencilerin tanılama, yerleştirme ve izleme sürecinde yaşanan sorunları tespit etmektir. Araştırama nitel araştırmalardan olgu bilim deseninde gerçekleştirilmiştir. Araştırmanın çalışma grubunu, 2020-2021 öğretim yılında Güneydoğu Anadolu Bölgesinin bir ilinde rehberlik ve araştırma merkezinde görev yapan sekiz özel eğitim uzmanı oluşturmaktadır. Araştırmanın verileri yarı yapılandırılmış görüşme formu ile toplanmıştır. Veriler içerik analizi tekniğiyle çözümlenmiştir. Elde edilen veriler sonucunda özel gereksinimli göçmen öğrencilerin tanılanmasının ilk aşamasında; farkında olmama, gereksiz görme, özentisiz davranma, yeterince bilgiye sahip olmama gibi yönetim, öğretmen ve veli kaynaklı sorunlar yaşandığı belirlenmiştir. Tanılama, yerleştirme ve izleme sürecinde dil yeterliliği, öğretmen gözlemi, tanılamada kullanılan materyallerin ölçme geçerliği ve güvenirliği, tanılama yapan uzmanların yeterliği, kurumlar arasında destek ve koordinasyonu sağlama ve öğretmen, öğrenci, yönetim veli arasındaki iletişim konularında sorunlar yaşandığı tespit edilmiştir. Araştırmada özel gereksinimli göçmen öğrencilerin en çok öğrenme güçlüğü alanında, en az ise özel yetenek alanında tanılamalarının gerçekleştirildiği sonucuna ulaşılmıştır.
Aim Undescended testis (UT) is a congenital genitourinary system pathology characterized by the absence of testis in the scrotum. In this disease, the heat stress caused by the testis not being at the optimal temperature can trigger oxidative stress (OS) and inflammation. Our study investigated the status of OS and inflammation markers between patients with undescended testes and healthy infants. Materials and Methods Fifty pediatric patients with undescended testes and a control group who applied to Pediatric Surgery Clinic were included in the study. From the blood samples, OS and inflammation status were examined. IL1β, IL6, TNFα levels of inflammation parameters were measured by ELISA method using commercial kits. Total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), and native thiol (NT) levels were measured photometrically with commercial kits. Oxidative stress index (OSI) and disulfide (DS) levels were calculated with a mathematical formula. SPSS 25.0 program was used in the statistical analysis of the data. Results TAS, TT, and NT levels were statistically significantly lower in the patient group than the healthy group (p
A ttention-deficit and hyperactivity disorder (ADHD) is one of the most common psychiatric diseases worldwide, affecting 5-12% of children. ADHD is a neurodevelopmental disorder characterized by inattention, distraction, restless excessive activity, impulsivity, and other deficiencies of executive functions [1].The role of nutrition in the etiology of ADHD is a topic under investigation. Although many studies have been conducted on nutrients and their components, the results are inconsistent with each other. Common findings in studies investigating the relationship between diet models and ADHD has been associated with unhealthy dietary mod-ABSTRACT OBJECTIVE: Attention-deficit hyperactivity disorder (ADHD) has been linked to "unhealthy" food consumption, but the studies in this area are insufficient. The aim of this study is to investigate the relationship between ADHD/related symptoms and processed meat products and snack consumption. METHODS:This study was conducted on 390 children aged between 6 and 17 with 169 ADHD (38 Girls, 131 Boys) and 221 healthy controls (93 Girls, 128 Boys). Food consumption was evaluated by a modified food frequency questionnaire, including 18 food containing processed meat products and snacks. ADHD symptoms were evaluated by the teacher and parent Turgay DSM-IV-Based Child and Adolescent Disruptive Behavioral Disorders Screening and Rating Scale (T-DSM-IV-Scale) and Conners' Rating Scale (CPRS, CTRS). RESULTS:Children with ADHD consumed more processed meat products, milk-based desserts, and chocolate-sweets than controls (p<0.05). A positive correlation was observed between the ADHD symptom scores and the consumption amount of all snacks, the amount of chocolate-sweets consumption, the frequency of consumption of sujuk, chocolate, jelly beans, sweets, cakes, and chocolate spread (p<0.05). CONCLUSION:Children with ADHD consume more foods rich in saturated fat and sugar than their healthy peers. Processed food consumption of children with ADHD may be associated with ADHD symptoms.
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