Background: Newcastle disease virus (NDV) genotype VII has become the dominant genotype in China. However, NDV genotype II was used to make current commercial NDV vaccines. The mismatch of genotypes between circulating and vaccine strains of viruses may compromise the efficacy of vaccines. Methods:In this study, a current circulating NDV was attenuated by mutations of multiple basic amino acid motif of fusion cleavage site 112 RRQKGF 117 based on reverse genetic techniques. The recombinant virus was prepared as an inactivated vaccine to test its efficacy and compared with a commercial LaSota NDV vaccine on SPF chickens.Results: All vaccinated chickens survived by the end of the study. By contrast, the unvaccinated chickens were all dead before 5 days post-challenge (DPC). Compared to commercial LaSota vaccine, the experimental inactivated vaccine elicited earlier and higher titer of HI antibodies and had reduced titer and duration of virus shedding after challenge. Conclusion:The experimental inactivated NDV vaccine may work as a promising vaccine candidate to control the disease.NDV genotype II strains [7]. The cross-protection of vaccines to genotype VII virus was seldom explored. In this study, we developed an inactivated NDV genotype VII vaccine based on reverse genetic techniques and compared its efficacy with commercial LaSota vaccine on SPF chickens. Material and methods VirusNDV strain PLK-N-06 was isolated from an outbreak of ND in chickens and identified as velogenic [intracerebral pathogenicity index (ICPI) = 1.79, mean death time (MDT) = 49 h]. Phylogenetic analysis results showed that it belongs to NDV genotype VIId. The virus was grown in 10-day-old embryonated SPF chicken eggs. Allantoic fluid was collected for use.
In this paper, we investigate the dynamically tunable plasmon-induced transparency (PIT) effects in parallel black phosphorus nanoribbons (BPNRs). The results show that the BPNRs having different lengths can be regarded as bright modes. Single-band, double-band, triple-band, and multi-band PIT effects based on the bright-bright mode coupling between parallel BPNRs are achieved. The physical mechanism of the single-band model can be explained theoretically by the radiating two-oscillator (RTO) model. Due to the heavier effective mass in the zigzag (ZZ) direction of the BP, the frequencies of the transparent peaks are shifted to lower frequencies when the placement directions of BPNRs are changed from the X-direction to the Y-direction.Furthermore, the resonant frequencies of the transparent windows in each model can be tuned by changing the relaxation rates of the BPNRs. The frequencies of the transparent windows are blue-shifted as the relaxation rates are increased. Finally, The corresponding sensors based on single-band PIT effect show high sensitivities of 7.35 THz/RIU. Our study has potential applications for improving the design of multiple-band filters, sensors and on-off switcher .
In this paper, a dual-controlled tunable polarization-independent triple-band absorber using hybrid bulk Dirac semimetal (BDS) and vanadium dioxide (VO2) metamaterial is proposed. The physical properties of the absorber can be theoretically analyzed by the equivalent circuit model (ECM). When the Fermi energy of BDS increases from 0.11 eV to 0.15 eV, the peak frequencies also gradually increase and blue shift occurs. In addition, When the VO2 is in fully metallic state, the absorber exhibits three distinct absorption peaks with absorptances of 99.76%, 99.61% and 99.76%, respectively, with an average absorptance of 99.71%. As the the transition of VO2 from fully metallic state to insulating state, the transmittance and reflectance increase and the absorptance gradually decreases. Moreover, due to the structure symmetry of the absorber, the absorptance exhibits polarization independent behavior. Finally, the modulations of absorptivity spectra by tailoring the structure dimension and the potential for the application of the absorber as a refractive index sensor, are further discussed. This study provides potential applications in the design of multi-band dual–controlled tunable sensors, filters and absorbers.
In this paper, we investigate the dynamically tunable plasmon-induced transparency (PIT) effects in parallel black phosphorus nanoribbons (BPNRs). The results show that the BPNRs having different lengths can be regarded as bright modes. Single-band, double-band, triple-band, and multi-band PIT effects based on the bright-bright mode coupling between parallel BPNRs are achieved. The physical mechanism of the single-band model can be explained theoretically by the radiating two-oscillator (RTO) model. Due to the heavier effective mass in the zigzag (ZZ) direction of the BP, the frequencies of the transparent peaks are shifted to lower frequencies when the placement directions of BPNRs are changed from the X-direction to the Y-direction. Furthermore, the resonant frequencies of the transparent windows in each model can be tuned by changing the relaxation rates of the BPNRs. The frequencies of the transparent windows are blue-shifted as the relaxation rates are increased. Finally, The corresponding sensors based on single-band PIT effect show high sensitivities of 7.35 THz/RIU. Our study has potential applications for improving the design of multiple-band filters, sensors and on-off switcher.
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