Hematological manifestations of rheumatoid arthritis (RA) are very common. Blood dyscrasias and other hematological abnormalities are sometimes the rst sign of rheumatic disease. In addition, novel anti-rheumatic biological agents may cause cytopenias. It is crucial that hematologists be aware of these presentations so that they are diagnosed and treated in a timely manner. A logical approach using easily available tests should allow straightforward decisions about diagnosis and therapy to be made, even in patients with some of the rarer hematological manifestations. An observational study was done in RA patients in a tertiary care hospital to study the prevalence and the type of hematologic manifestations from a pathologist's perspective. It was observed that anemia is the most common hematologic nding seen in RA, iron deciency being the commonest cause of anemia, however hemolytic anemia was not seen. Leucocytosis was more common with predominant neutrophilia. Elevated platelet count, bicytopenia and pancytopenia were observed in RA along with raised ESR. Coagulation parameters were however within normal range. Bone marrow ndings (where studied) included tuberculosis and plasma cell neoplasm. Summary: This study was conducted to estimate the proportion of patients with hematological abnormalities as the manifestation of RA and to study the nature of these various hematological problems, so that the empirical treatment can be started and also to inform the clinical rheumatologists about the common and rarer hematological manifestations of RA.
Background: Systemic lupus erythematosus (SLE) can present with hematologic manifestations alone or with features of systemic involvement. Diagnosis may be delayed or missed at presentation time, especially in those with hematologic abnormalities as the initial manifestation, with low index of clinical suspicion or inadequate follow-up. Aim And Objectives: To study the prevalence and the type of hematologic manifestations in SLE from pathologist's perspective. Setting And Design: Retrospective observational study. Material And Methods: Study was done in 63 SLE patients in a tertiary care hospital in Secunderabad for duration of one and half years, from January 2018 to June 2019. Hematological parameters of the same were retrieved. Results :It was observed that anemia was the most common hematologic nding with iron deciency anemia (IDA) being the commonest cause followed by hemolytic anemia. Leucopenia with predominant lymphopenia was the most common WBC abnormality and thrombocytopenia was seen in majority of the patients. Bi and pancytopenia was also observed. Raised erythrocyte sedimentation rate (ESR) was a common nding. Deranged coagulation prole was seen due to secondary anti-phospholipid antibody (APLA) syndrome, hemolysis and sepsis on anticoagulant. Bone marrow studies showed varied ndings including hypocellularity, dyspoiesis in the erythroid, myeloid and megakaryocytic series and abnormal localisation of immature precursors (ALIP) aggregates. Conclusion: This study was conducted to estimate the proportion of patients with hematological abnormalities as the manifestation of SLE and to study the nature of hematological problems, so that the empirical treatment can be started.
Background: Cervical cancer is the fourth leading cause of death in females worldwide. In India cervical cancer is the leading cause of morbidity and mortality. Cancer of cervix is preventable, and can be diagnosed at the pre-malignant stage with adequate and repetitive cytological screening by Papanicolaou (Pap) smears. Aim of this study was to study the role of Pap smear in detecting premalignant and malignant lesions as well as non-neoplastic lesions of cervix. Methods: It is a retrospective study of 240 pap smears studied from January 2022 to June 2022 and received in pathology department of a tertiary care hospital of north Maharashtra. Samples are collected from women between 21 to 65 years presenting with some gynecological problems. Smears were reported as per the 2014 Bethesda system. Results: Out of 240 women, 216 were having normal cytology and 146 cases with inflammatory changes. 10 cases were unsatisfactory. 5 cases of ASCUS, 1 case of SCC, 2 cases of HSIL and 6 cases of LSIL were observed. Conclusions: Pap smear test is a simple, safe, noninvasive, economical OPD based procedure to detect pervasive cervical epithelial lesions. Every woman should undergo Pap test at least once in her life before the age of 45 years.
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