This study aims to evaluate the vitamin D receptor (VDR) expression and intracellular amounts of VDRs in CD4+ and CD8+ lymphocytes of renal transplant (RT) recipients with chronic allograft dysfunction (CAD). A total of 43 patients (Group 1:RT patients=29 patients, 15 patients CAD proven by renal biopsy (Group 1a), 14 patients stable renal function (Group 1b), Group 2:Control group=14 healthy individuals) have been enrolled in this study. 25-hydroxycholecalciferol, 1.25 dihydroxycholecalciferol levels were measured. The number of cells expressing VDR among the CD4+ and CD8+ type T lymphocytes of the subjects was determined as % of those cell groups. The mean VDR molecule contents per cell have been measured and expressed as mean fluorescence intensities (MFI). No difference was found between Group 1 and Group 2 in terms of their 25-hydroxycholecalciferol, 1.25 dihydroxycholecalciferol levels, and the percentages of the cells expressing VDR in CD4+ and CD8+ cells (p>0.05). CD4+/VDR(MFI) and CD8+/VDR(MFI) values were higher in RT patients than healthy subjects (p<0.001). When the RT patient subgroups compared, there were no statistically significant differences regarding CD4+/VDR(%), CD8+/VDR(%), CD4+/VDR(MFI) and CD8+/VDR(MFI) values (p>0.05). This study showed VDR in T lymphocytes of patients who had RT did not change, but the VDR content in the cells increased due to reasons independent of serum 25hydroxycholecalciferol and 1.25 dihydroxycholecalciferol levels.
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