Aim: It was aimed to investigate the clinical course of the Omicron vand Delta variant among the SARS-CoV-2 vaccinated and unvaccinated COVID-19 patients over 65 years old and to compare their effects on patients. Material and Method: The study was conducted on 567 COVID-19 patients over 65 years old. All patients’ gender, age, medical history, COVID-19 PCR test results, blood test results, thorax CT images, vaccination status, hospitalization status, and treatment results were recorded. When evaluating the chest CT images, a semiquantitative scoring system was used. The patients were divided into the Omicron and Delta variant subgroups, and vaccinated and unvaccinated groups. Comparisons were made between the Delta variant and Omicron variant groups, the vaccinated and unvaccinated patient groups,and SARS-CoV-2 mRNA vaccinated and inactivated SARS-CoV-2 vaccinated patient groups. Results: A total of 519 patients were included in the study.337 patients were in the Omicron variant group, 182 were in the Delta variant group.The hospitalization rate, ICU admission rate, mortality rate, rate of symptomatic patients,and the median thorax CT severity score was significantly higher in the Delta variant group than the Omicron variant group.The hospitalization rate, ICU admission rate, mortality rate, median thorax CT score and the rate of asymptomatic patients was significantly higher in the unvaccinated patient group than in the vaccinated group.There was no significant difference in the mortality rates and in the ICU admission rates between the inactivated SARS-CoV-2 vaccinated group and the SARS-CoV-2 mRNA vaccinated group. Conclusion: The SARS-CoV-2 Omicron variant compared to the Delta variant and the SARS-CoV-2 vaccinated patients compared to the unvaccinated patients had a milder clinical course and less mortality in COVID-19 patients over 65 years old.

Aim:We aimed to determine the frequency of troponin elevations in COVID-19 patients and to investigate the role of troponin in demonstrating the prognosis of COVID-19 by examining the clinical course of theese patients. Material and Method: Patients diagnosed with COVID-19 disease were included in the study. Patient files were analyzed retrospectively through the hospital information management system.Patients with high troponin levels were identified and comparisons were made with patients with normal troponin levels. Results: 1468 patients were included in the study.Troponin level was found to be high in 6.7% of the patients.The presence of pneumonia on thorax CT rate,hospitalization rate,ICU admission rate,intubation rate was significantly higher in patients with high troponin levels.The mortality rate was 2.1% in the whole group.The mortality rate was significantly higher in the patients with high troponin levels.Total length of hospital and ICU stay were significantly higher in patients with high troponin levels. There was a significant positive correlation between the troponin levels of the patients at admission and the total length of hospital stay and length of ICU stay. 49.5% of COVID-19 patients had another comorbid disease.Hypertension was the most common comorbid disease. The rate of troponin elevation and troponin levels were significantly higher in patients with other comorbid diseases. Conclusion: It has been found that high troponin levels in COVID-19 patients may be associated with a poor clinical prognosis. Troponin can be used as a predictor of prognosis with more comprehensive studies and long-term follw-up results in the future.

Introduction: Hypocalcemia is a condition that can occur in malignant diseases due to tumor lysis syndrome or chemotherapy agents. Hypocalcemia due to hypoparathyroidism accompanying malignancy is very rare. We, in this report are sharing a case of metastatıc breast carcinoma with treatment -resistant hypocalcaemia.Case Report: A 37-year-old woman who was diagnosed and followed-up with panhypopituitarism and contractions throughout the body after a recent child delivery. On the basis of the positive chvostek and trausseu findings on the physical examination of the patient we did hypocalcemia work-up and found plasma calcium: 5.4mg/dl, phosphorus: 7.8mg/dl, albumin: 4g/dl, 25-OH vitamin D3: 18.7ng/ml and parathormone as <3pg/ml. Considering primary hypoparathyroidism, calcium carbonate and calcitriol treatments were applied. However, ca-gluconate infusion was initiated on the basis that calcium levels remained at 6.5mg/dl. In the cranial-pituitary MRI examination there were multiple millimetric nodular lesions of in cerebral and cerebellar hemispheres. PET/CT revealed a hypermetabolic area of malignant character in the lower quadrant of the left breast which can represent the primary tumor and multiple hipermetabolic areas in axial skeleton showing the most prominent activity in C2 and T6 vertebra. The biopsy result from the mass in the breast was reported as invasive lobular carcinoma and the patient was referred to the oncology department.Discussion: Hypoparathyroidism may develop due to surgery, autoimmune or destruction in the parathyroid gland. The cause of hypoparathyroidism, which further complicated the treatment of hypocalcemia in our patient, may be due to metastasis or to the possible autoimmune mechanisms or PTHrP. Osteoblastic metastasis and PTHrP may have been found at the same time, and this cycle may have shifted towards osteoblastic activity. We can't find any association between breast cancer and autoimmune hypoparathyroidism in the literature. Conclusion:Although there are other reasons that complicate the clinical status in treatment-resistant hypocalcemia patients, it should be considered that there may be an underlying malignancy.

A transformation reaction from anionic to metathesis was used to prepare block copolymers of styrene and cyclopentene. The composition of the products was established by elemental and UV analysis. A mechanism for the formation of the propagating centre in the olefin metathesis reaction was postulated that will account for the incorporation of the alkyl group of the cocatalyst in the first formed metal carbene.

Aim:We aimed to investigate the prevalence of diabetes in COVID-19 patients and the effect of diabetes on the course of COVID-19 disease. Material and Methods:Patients diagnosed with COVID-19 disease in Istanbul Sancaktepe Martyr Prof. Dr. Ilhan Varank Training and Research Hospital between 01/06/2020 and 30/10/2020 were included in the study. Medical records of patients were analyzed from the hospital information management system. We examined medical history, PCR test results, blood test results, computerised tomography reports, hospitalization and treatment results.Results: 2414 patients, 1145 females and 1269 males were included in the study. The diabetes prevalence in the whole group was 18.6%. The rate of hospitalization and the rate of admission to intensive care unit was significantly higher in diabetics than non-diabetics. In the diabetic group; total length of stay in hospital and intensive care unit was significiantly higher. The rate of presence of pneumonia on tomography was significantly higher in diabetics. The mortality rate was significiantly higher in diabetics than non-diabetics. Conclusion:We found the prevalence of diabetes in COVID-19 patients to be 18.6%. The rate of presence of pneumonia on thorax CT, the rate of hospitalization and the rate of admission to the intensive care unit were found to be significantly higher in diabetics. The mortality rate was found to be higher in COVID-19 patients with diabetes. Diabetes mellitus may lead to worse clinical outcomes in COVID-19 patients. COVID-19 may be more mortal in diabetic patients.