Coffee roasting affects the taste, color, and aroma of coffee. The Maillard reaction, a major reaction during the roasting process, produces melanoidin, which affects the overall antioxidant capacity and anti-inflammatory effects of coffee. In this experiment, coffee roasting was divided into four degrees: Light, Medium, City, and French. To examine the in vivo antioxidant and anti-inflammatory effects of coffee extracts with different roasting degrees, we used 10-week-old male C57BL/6 mice. Mice were pre-treated with coffee extracts for 10 days by oral gavage (300 mg/Kg.B.W). After the last pre-treatment, lipopolysaccharide (LPS, 15 mg/Kg.B.W) was injected intraperitoneally for immune stimulation. Histopathological analysis showed that hepatic portal vein invasion and liver necrosis were severe in the LPS-treated group. However, these phenomena were greatly ameliorated when mice were pre-treated with Light- or Medium-roasted coffee extracts. Hepatic glutathione level was increased in the French group but decreased in the LPS-stimulated group. When mice were treated with LPS, mRNA expression level of tumor necrosis factor-alpha (TNF-α) was increased, whereas TNF-α expression was significantly reduced in the Light and Medium groups. Treatment with coffee extracts decreased the mRNA expression levels of interleukin 6 (IL-6) in mice stimulated by LPS, regardless of coffee roasting degrees. These effects decreased with the increasing coffee roasting degree. Results of luciferase reporter assay revealed that these effects of coffee extracts were transcriptionally regulated by the NF-κB pathway. Taken together, these results suggest that the roasting degree affects the antioxidant and anti-inflammatory effects of coffee extracts.

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This study examined how self-presentation on social media influences the way people view themselves. It also examined whether that varies with sites using two temporal features: posts which have a short life (ephemeral) and those which live indefinitely (permanent). Drawing on both the notion of public commitment and self-symbolizing, our experiment provided a critical test of two rival theory-driven hypotheses—one suggesting a greater internalization of presented self on permanent rather than ephemeral social media and the other suggesting the opposite pattern. Supporting the self-symbolizing perspective, those who publicly presented themselves on ephemeral social media internalized their portrayed personality. Also, such a difference in internalization between the two conditions was triggered by an introverted self-presentation. Results suggest that ephemerality enhances self-symbolizing efforts and the subsequent internalization by affording nonstrategic self-presentation and reducing impression management concerns. Implications for understanding self-concept change in social media contexts are discussed.

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