Poly(decamethylene terephthalamide) PA10T with different relative viscosities (RV) were successfully produced by the reaction of 1,10-decanediamine and terephthalic acid through molecular weight regulator benzoic acid (BA). RV was shown to be decreased linearly with increasing BA concentrations and detailed structures of PA10Ts were characterized by 13 C-NMR. Fluidity of PA10T with varying molecular weight was tested and low RV PA10Ts were used as modifiers to improve fluidity behaviors of high RV PA10Ts, meanwhile mechanical properties were maintained.
ABSTRACT:The miscibility of blends of bisphenol-A-polycarbonate (BAPC) with the terpolymer poly(hydroxystyrene-co-acrylonitrile-co-styrene) (OHS-AN-S) and the copolymer poly(hydroxystyrene-co-acrylonitrile) (OHS-AN) was investigated. BAPC was found to be miscible with terpolymers incorporating 25-80 mol % hydroxystyrene. The introduction of the acrylonitrile monomer (AN) into poly (styrene-co-hydroxystyrene) (PSHS) produces a wider ''miscibility window'' with BAPC compared with that of blends of BAPC with PSHS i.e. a miscible blend is obtained at relatively lower levels of hydroxyl groups in the terpolymer. However, the miscibility range in terpolymer/BAPC blends is affected by the amount of AN monomer incorporated into the terpolymer. This is probably a consequence of the influence of the AN monomer on the closer spatial correlation between the terpolymer and BAPC chains. BAPC is also found to be miscible with the OHS-AN copolymer within the composition range 12-50 AN mol % in the copolymer. A triangular phase diagram for binary blends of terpolymer/ homopolymer (A x B y C z /D) is suggested, to determine the miscible region of the terpolymer compositions in the blends. A model used for predicting the miscibility of binary blends consisting of a homopolymer and a terpolymer was also proposed on the basis of the mean-field theory, and tested with the experimental results obtained in this work.
Mitophagy modulators are proposed as potential therapeutic intervention that enhance neuronal health and brain homeostasis in Alzheimer's disease (AD). Nevertheless, the lack of specific mitophagy inducers, low efficacies, and the severe side effects of nonselective autophagy during AD treatment have hindered their application. In this study, the P@NB nanoscavenger is designed with a reactive‐oxygen‐species‐responsive (ROS‐responsive) poly(l‐lactide‐co‐glycolide) core and a surface modified with the Beclin1 and angiopoietin‐2 peptides. Notably, nicotinamide adenine dinucleotide (NAD+) and Beclin1, which act as mitophagy promoters, are quickly released from P@NB in the presence of high ROS levels in lesions to restore mitochondrial homeostasis and induce microglia polarization toward the M2‐type, thereby enabling it to phagocytose amyloid‐peptide (Aβ). These studies demonstrate that P@NB accelerates Aβ degradation and alleviates excessive inflammatory responses by restoring autophagic flux, which ameliorates cognitive impairment in AD mice. This multitarget strategy induces autophagy/mitophagy through synergy, thereby normalizing mitochondrial dysfunction. Therefore, the developed method provides a promising AD‐therapy strategy.
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