Background: Takotsubo cardiomyopathy (TSC) and its complications, such as cardiac rupture (CR), are increasingly being reported in the literature. CR is associated with rapid clinical decline and is uniformly fatal if not surgically repaired. To identify patients who developed CR we performed an analysis of all available indexed cases in the literature and compared them with a control group of patients with TSC without rupture. Hypothesis: Takotsubo cardiomyopathy patients with cardiac rupture do not differ significantly from those without rupture. Methods: MEDLINE (2009) was searched for all TSC case reports with CR. Eleven case reports were identified. Using a random sampling method, we selected 12 case reports of TSC without rupture (control). We included our patient with TSC with rupture as the 12th case of TSC cohort with CR (CR group). Demographic and clinical characteristics were compared between CR group and control. Results: All patients in the TSC group with rupture were female and were significantly older than controls. TSC group with rupture had significantly higher frequency of ST elevation in lead II and absence of T-wave inversion in lead V5 on hospital admission than controls. Mean ejection fraction, systolic blood pressure, and double product, a measure of oxygen demand, was significantly higher in the rupture group compared to controls. The CR group was associated with less frequent use of β-blocker as compared to controls. Conclusions: CR as a complication of TSC could be more common than recognized. Higher double product and ejection fraction suggest higher fluctuation of intracardiac pressure and may cause CR in TSC. Use of β blockers in TSC may provide protection against CR. Methods Ovid MEDLINE (1950-2009) was searched for case reports with search terms ''Takotsubo cardiomyopathy,'' ''Takotsubo syndrome,'' ''stress cardiomyopathy,'' ''ampullary cardiomyopathy,'' and ''broken heart syndrome.'' A total of 375 case reports were identified with ''human'' and ''English'' as limits. Eleven case reports of TSC were identified with CR. All case reports were published during the years 2004 to 2009. To obtain a control group for comparison we searched MEDLINE for case reports with the same search terms spanning 2004 to 2009. We chose a random sampling method using a random number generator to select case reports. If the article matching the random number was not a case

Here we deal with a nonlocality argument proposed by Cabello, which is more general than Hardy's nonlocality argument, but still maximally entangled states do not respond. However, for most of the other entangled states, maximum probability of success of this argument is more than that of the Hardy's argument.

Gisin's theorem assures that for any pure bipartite entangled state, there is violation of Bell-CHSH inequality revealing its contradiction with local realistic model. Whether, similar result holds for three-qubit pure entangled states, remained unresolved. We show analytically that all three-qubit pure entangled states violate a Bell-type inequality, derived on the basis of local realism, by exploiting the Hardy's non-locality argument.

We analyze Hardy's non-locality argument for two spin-s systems and show that earlier solution in this regard was restricted due to imposition of some conditions which have no role in the argument of non-locality. We provide a compact form of non-locality condition for two spin-s systems and extend it to n number of spin-s particles. We also apply more general kind of non-locality argument still without inequality, to higher spin system.

The ontological model framework for an operational theory has generated much interest in recent years. The debate concerning reality of quantum states has been made more precise in this framework. With the introduction of generalized notion of contextuality in this framework, it has been shown that completely mixed state of a qubit is preparation contextual. Interestingly, this new idea of preparation contextuality has been used to demonstrate nonlocality of some ψ-epistemic models without any use of Bell's inequality. In particular, nonlocality of a non maximally ψ-epistemic model has been demonstrated from preparation contextuality of a maximally mixed qubit and Schrödinger's steerability of the maximally entangled state of two qubits (Leifer and Maroney, Phys Rev Lett 110:120401, 2013). In this paper, we, show that any mixed state is preparation contextual. We, then, show that nonlocality of Recently, M. S. Leifer have written a review on ψ-ontology theorems [32]. Among many open questions listed in there one is concerned about preparation contextuality proof for any mixed quantum state. This question is addressed in our paper and we have answered affirmatively. 1231 any bipartite pure entangled state, with Schmidt rank two, follows from preparation contextuality and steerability provided we impose certain condition on the epistemicity of the underlying ontological model. More interestingly, if the pure entangled state is of Schmidt rank greater than two, its nonlocality follows without any further condition on the epistemicity. Thus our result establishes a stronger connection between nonlocality and preparation contextuality by revealing nonlocality of any bipartite pure entangled states without any use of Bell-type inequality.