The use of catalytic amount of metal acetate or metal oxide in acetic acid is a new and highly efficient acetylating system for chemoselective N-acetylation of primary and secondary amines in excellent yields under reflux condition. No other solvent is required. The noted features of this method include mild reaction conditions, use of innocuous reagents, excellent yields, convenient work-up, and reuse of catalyst.
A simple and efficient protocol has been developed for the synthesis of biologically relevant 2-substituted benzimidazoles and quinoxalines using magnetically separable manganese ferrite (MnFe 2 O 4 ) nanopowder for the first time as a reusable heterogeneous catalyst at room temperature under aerobic conditions. MnFe 2 O 4 nanoparticles were prepared by a simple sol-gel method using starch as a bio-polymeric matrix, and characterized by XRD, TEM, EDAX and VSM analyses.
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