An anti-gpl20 monoclonal antibody (MAb), C108G (-yl, K), was isolated from a chimpanzee that had been infected with strain IIIB of human immunodeficiency virus type 1 (HIV-l111B) and subsequently immunized with the recombinant glycoprotein rgpl60MN. This MAb is specific for the IIIB strain of HIV-1 and related clones and exhibits very potent neutralization of these viruses; e.g., 100% neutralization of approximately 8 x 103 infectious units of HXB2 was achieved with 125 ng of C108G per ml. Commensurate with this potent
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