There are four principles of medical ethics; Beneficence, Respect for autonomy, Non-maleficence, and Justice. It is not easy to apply to principles of medical ethics in the special circumstances of obstetrics and gynecology. Student doctors must learn to be familiar with principles of medical ethics tailored to the special circumstances while the obstetrics and gynecology practice.
Background Newborn screening for congenital adrenal hyperplasia (CAH) has
benefits with a high adoption rate worldwide. It also has problems of high false
positives, which can cause stress to the patient’s family with economic
losses and unnecessary visits of newborns to hospitals. Therefore, we
investigated the influence of birth weight (BW), gestational age (GA), and GA
with sampling time on 17-hydroxyprogesterone (17-OHP) concentration and
attempted to establish the 17-OHP cutoff values in preterm, low birth weight
(LBW), and sick newborns.
Methods Newborns (n=1,071) born between October 2020 and January
2022 were screened for CAH. Samples from neonates were collected on filter paper
with the heel prick method. 17-OHP concentration was measured by time-resolved
immunofluorescence with an AutoDELFIA Neonatal 17-hydroxyprogesteron kit and
grouped in relation to BW, GA, and GA with sampling time.
Results The median age of newborns at neonatal sample collection was 6
days. 17-OHP concentration showed a statistically significant negative
correlation with BW (r=−0.488, p<0.001)
and GA (r=−0.560, p<0.001). Full-term and
preterm subgroups had a similar decreasing tendency of 17-OHP concentration with
increasing sampling time. Application of newly establishing cutoff criteria
significantly reduced recall rates to 1.16%, 0.9%, and
1.75% according to each criterion of BW, GA, and GA with sampling time,
respectively.
Conclusions This study presents new 17-OHP cutoff values for preterm, LBW,
and sick newborns. These data in our laboratory can be used as a reference by
other laboratories for establishing new cutoff criteria to help lower the high
recall rate and reduce unnecessary follow-up tests.
Background: We investigated the importance of lupus anticoagulant (LA) in patients with SARS-CoV-2. Methods: Medical records of 41 SARS-CoV-2 infected patients were reviewed. Patients were classified into two groups according to the frequency of positive LA test results: “LA (−)” and “LA (+) ≥1” (LA positive at least once). Statistical analysis was performed to determine the association between LA presence and change in LA test results and disease course according to both hospital days (HD) and days after diagnosis (DD). Results: The prevalence of LA was 51.2%. Averagely, the first change in LA test result occurred during DD 12-13 and between HD 9-10. The second change occurred on DD 15-16 and HD 13-14. The presence of LA was associated with severe disease ( P = .004) but was not associated with thrombotic complications or mortality. The change of results from negative to positive or vice versa or the frequency of the changes was not associated with disease severity, thrombotic complications, or mortality. Conclusions: LA positivity can be regarded as one of the findings suggesting more serious SARS-CoV-2 infection.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.