Discrete
oligo- and polyesters are highly attractive for a wide
range of investigations because of their great fidelity on structure–property
relationships. Even though numerous synthetic approaches have been
developed, a more versatile synthetic platform with broad group tolerance
is still desired. Herein, we report an iterative exponential growth
strategy for efficient synthesis of discrete oligo- and polyesters,
employing an optimized protective group pair, namely, TBDPS ether
and t-butyl ester. The versatility of the strategy
is demonstrated by facile preparation of several structurally diverse
discrete oligo- and polyesters under mild, safe, and scalable reaction
conditions, with the number of repeat units up to 256. Moreover, the
contributions of the terminal protective groups on the melting and
crystallization behaviors of discrete oligo- and poly(ε-caprolactone)s
were investigated. With this robust synthetic platform, various functional
moieties can be readily incorporated into polyester chains, and a
myriad of applications of polyesters could thus be reasonably anticipated.
Palindromic sequence-induced specific and genetic functions widely exist in biological systems. Nevertheless, the study of synthetic palindromic sequence-defined polymers has received rare attention due to the challenge of efficient synthesis....
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