Human subjects were infected with Haemophilus ducreyi. All subjects developed papules and were randomized to treatment with a single dose of azithromycin (1 g) or ciprofloxacin (500 mg). At weekly intervals, volunteers were reinoculated with H. ducreyi, and drug concentrations were measured in peripheral blood mononuclear cells (PBMC). When papules developed, the subjects were treated with antibiotics and dismissed from the study. Eight of the ciprofloxacin-treated subjects developed papules 1 week after the initial treatment, and the ninth subject developed disease 2 weeks after treatment. The 9 azithromycin-treated subjects developed papules 4-10 weeks (mean, 6.8) after the initial treatment (P < .001). Azithromycin was detected in PBMC for 3-6 weeks (mean, 4). Pre- and posttreatment lesions had histology typical of experimental chancroid or were culture positive. Azithromycin prevents experimental chancroid for nearly 2 months. These findings have implications for strategies to prevent chancroid.

Considering cost, efficacy, and safety, timolol maleate is the recommended formulary agent because the other agents cannot consistently show an outstanding advantage.

The vastness and diversity of the Internet make it an emerging choice as an information repository and dissemination mechanism for healthcare-related information. The objective of this research is to characterize empirically the use of the Internet by a variety of healthcare professionals as well as to gauge perceptions of the Internet as a tool for information retrieval. This was accomplished through use of a questionnaire explicitly designed to gauge usage and perceptions of the Internet. Differences were detected between individual occupations of healthcare professionals with respect to Internet use and opinions concerning possible enhancements to the Internet. It was found that users' subjective experiences with the World-Wide Web (WWW) were more important than self-reported user knowledge when indicating the value of enhancements to the search process on the WWW. The methodological implications of the research together with a conceptual framework for usability that captures the essence of Internet usability in healthcare are presented. Directions for future research are provided.

Several potential advantages of adding hydroxyurea to antiretroviral treatment regimens include the drug's well-documented toxicity, convenient dosing, good tolerability and low cost, and its unique mechanism of action. Hydroxyurea may have synergistic effects that prove promising in initial and salvage therapy antiretroviral regimens. Larger, well-controlled clinical studies are needed to adequately define the role of hydroxyurea in the treatment of HIV.