While modern parallel computing systems offer high performance, utilizing these powerful computing resources to the highest possible extent demands advanced knowledge of various hardware architectures and parallel programming models. Furthermore, optimized software execution on parallel computing systems demands consideration of many parameters at compile-time and run-time. Determining the optimal set of parameters in a given execution context is a complex task, and therefore to address this issue researchers have proposed different approaches that use heuristic search or machine learning. In this paper, we undertake a systematic literature review to aggregate, analyze and classify the existing software optimization methods for parallel computing systems. We review approaches that use machine learning or meta-heuristics for software optimization at compile-time and run-time. we discuss challenges and future research directions. The results of this study may help to better understand the state-of-the-art techniques that use machine learning and meta-heuristics to deal with the complexity of software optimization for parallel computing systems. Furthermore, it may aid in understanding the limitations of existing approaches and identification of areas for improvement.

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Abstract-Genetic information is increasing exponentially, doubling every 18 months. Analyzing this information within a reasonable amount of time requires parallel computing resources. While considerable research has addressed DNA analysis using GPUs, so far not much attention has been paid to the Intel Xeon Phi coprocessor. In this paper we present an algorithm for large-scale DNA analysis that exploits thread-level and the SIMD parallelism of the Intel Xeon Phi. We evaluate our approach for various numbers of cores and thread allocation affinities in the context of real-world DNA sequences of mouse, cat, dog, chicken, human and turkey. The experimental results on Intel Xeon Phi show speed-ups of up to 10× compared to a sequential implementation running on an Intel Xeon processor E5.

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The DNA sequence analysis is a data and computationally intensive problem and therefore demands suitable parallel computing resources and algorithms. In this paper, we describe an optimized approach for DNA sequence analysis on a heterogeneous platform that is accelerated with the Intel Xeon Phi. Such platforms commonly comprise one or two general purpose host central processing units (CPUs) and one or more Xeon Phi devices. We present a parallel algorithm that shares the work of DNA sequence analysis between the host CPUs and the Xeon Phi device to reduce the overall analysis time. For automatic worksharing we use a supervised machine learning approach, which predicts the performance of DNA sequence analysis on the host and device and accordingly maps fractions of the DNA sequence to the host and device. We evaluate our approach empirically using real-world DNA segments for human and various animals on a heterogeneous platform that comprises two 12-core Intel Xeon E5 CPUs and an Intel Xeon Phi 7120P device with 61 cores.