The oral hypoglycemic activity of Salacia reticulata extract was evaluated in streptozotocin induced diabetic rats. The diabetic rats were orally administered an aqueous extract of Salacia reticulata and the plasma glucose concentration was determined at regular intervals following administration. The drug was effective as a hypoglycemic agent at all the doses tested (0.5 g/kg, 1.0 g/kg and 5.0 g/kg). The maximum percentage decrease in plasma glucose was observed between 1-5 h following administration of the drug.

Three novel macrocyclic diterpepoids, 4,7-oxycyAbstract: The total synthesis of ethyl 3-carboline-1-propionate has been described and its ability to bind toward benzodiazepine and GABA receptors has been studied. It has been suggested that j3-carboline-1-propionic acid is the true natural product, its ester derivatives are only artefacts of the isolation procedure.

Dehydroevodiamine hydrochloride (0.1-0.3 mg/kg iv), which was isolated from the leaves of Evodia rutaecarpa, increased the cerebral blood flow recorded from the surface of the supra-sylvian gyrus in anesthetized cats. This action reached a maximum 1-4 min after injection and continued for 10 min. However, the compound had negligible effects on other cardiorespiratory functions at the doses examined. These results suggest that the compound selectively increases cerebral blood flow.

In the previous paper, we reported of rats treated chronically with ethanol; that side chain oxidation of hexobarbital, N-demethylation of aminopyrine and p-hydroxylation

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