Organophosphorus compounds are extensively used worldwide as pesticides which cause great hazards to human health. Nerve agents, a subcategory of the organophosphorus compounds, have been produced and used during wars, and they have also been used in terrorist activities. These compounds possess physiological threats by interacting and inhibiting acetylcholinesterase enzyme which leads to the cholinergic crisis. After a general introduction, this review elucidates the mechanisms underlying cholinergic and noncholinergic effects of organophosphorus compounds. The conceivable treatment strategies for organophosphate poisoning are different types of bioscavengers which include stoichiometric, catalytic, and pseudocatalytic. The current research on the promising treatments specifically the catalytic bioscavengers including several wild-type organophosphate hydrolases such as paraoxonase and phosphotriesterase, phosphotriesterase-like lactonase, methyl parathion hydrolase, organophosphate acid anhydrolase, diisopropyl fluorophosphatase, human triphosphate nucleotidohydrolase, and senescence marker protein has been widely discussed. Organophosphorus compounds are reported to be the nonphysiological substrate for many mammalian organophosphate hydrolysing enzymes; therefore, the efficiency of these enzymes toward these compounds is inadequate. Hence, studies have been conducted to create mutants with an enhanced rate of hydrolysis and high specificity. Several mutants have been created by applying directed molecular evolution and/or targeted mutagenesis, and catalytic efficiency has been characterized. Generally, organophosphorus compounds are chiral in nature. The development of mutant enzymes for providing superior stereoselective degradation of toxic organophosphorus compounds has also been widely accounted for in this review. Existing enzymes have shown limited efficiency; hence, more effective treatment strategies have also been critically analyzed.

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Analysis of long-term rainfall data (1986-2018) of Bastar region revealed decreasing trend in total quantum of annual rainfall with varying frequency and distribution. The quantity of winter and summer rains decreased drastically during 2008-18 as compared to earlier two decades (1986-96 and 1997-2007). SW monsoon rain of 2008-18 was more than past two decades, whereas NE monsoon rain changed much in quantity except during 1997-2007. During 1986-96, the pre-monsoon shower was received in April, but later two decades the shower was received in May, which supports for summer ploughing and dry aerobic seeding. The cropping period almost synchronized between 22-43 standard meteorological week (SMW) reaching 93.11 mm per week as maximum rainfall. As the probability of 20 mm rainfall decreased from 75 to 50%, the crop yield got reduced by 30%. The mid-land rice with a probability of 13.47 to 16.07 mm rain per week supported growth phase during 17-21SMW. Whereas, upland rice maturing in 90-100 days could avoid dry spells, if the rice is managed by conservation furrows at the time of sowing. The summer ploughing is preferred with more than 40 mm rain in single day during March to April for mitigating dry spells. On the other hand, preparatory tillage and sowing were performed together in support of ripening niger and horsegram under probability of 75, 50 and 25% rain through crop planning. Maize and small millets reduced yield  significantly when rainfall reached 75% deficit, whereas 25% deficit rain did not affect the yields.