Carbon–carbon/carbon–heteroatom bond formation via oxidative transformations is a heavily explored topic at the frontier of chemistry. Potassium persulfate (K2S2O8) has emerged as a cost-effective, suitable inorganic oxidant for a wide array of oxidative transformations, ranging from laboratory experiments to industrial processes. The current review provides a comprehensive coverage of oxidative transformations aided with K2S2O8 in the presence or absence of a transition-metal catalyst, critical assessment of the results, and underlying mechanisms. Organic chemists may find this review to be a useful guide for the expedient synthesis of new chemical entities, to formulate mechanistic manifolds involving the sulfate radical anion, or to design novel oxidative transformations. A detailed understanding of the unsolved mechanisms could further enrich the field.

This review describes the stereoselective synthesis of a γ-spirocyclic containing natural products or model compounds showing phytotoxic, antibiotic, anti-inflammatory, antiviral, antimicrobial, cytotoxic, and antitumor activities.

A new copper dimeric complex has been synthesized, characterized and used as a multifunctional material.

Total synthesis of proposed elgonene C (1) and its (4R,5R)-diastereomer (1a) has been synthesized by using second-generation oxazoborolidinium ion catalysed Diels-Alder reaction, Sharpless asymmetric dihydroxylation, and Ni-catalysed cross-carboxy coupling reaction...

A comprehensive account of transition metal free αÀ CÀ H functionalization of six membered heteroaromatic-N-oxides has been discussed in this review article. This review includes brief account of explanatory text with schemes, effect of substituents on the reaction and limitation of reaction for transition metal free αÀ CÀ H functionalization of six membered heteroaromatic-N-oxides. Schemes depict the reaction conditions along with a quick look into their mechanism. Each of the reported example has been considered for reacting substrates such as readily available different six membered heteroaromatic-N-oxides, activating reagents, reaction conditions and different types of nucleophiles (N, Halogens, P, S, C and O), reaction conditions and reagents used for transition metal free αÀ CÀ H functionalization of six membered heteroaromatic-Noxides. This review will be supportive to the chemists in understanding the challenges associated with the reported methods as well as the future potentials, both in the choice of substrates and reagents.