The study population included 1546 women. In subjects with prior sPTB, the rate of recurrent sPTB <32, <35 and <37 weeks was similar for each of the qfFN concentration intervals examined with or without treatment (Table). qfFN concentration was not associated with response to 17-P as rates of sPTB at each concentration interval were not reduced with 17-P and at 10-199 ng/ mL the sPTB rate was higher in 17-P treated women (p¼0.01,0.002, and 0.01 for <32, 35 and 37 wk, respectively). In women treated with vag P for a short cervix, sPTB rates increased as qfFN increased. In women with twins or short cervix who had a cerclage, the sPTB rate increased as qfFN increased. At qfFN concentration 10-199 ng/ mL the rate of sPTB was significantly higher in the cerclage group (p<0.001, 0.03, <0.001 for <32, 35 and 37 wk, respectively). CONCLUSION: Increasing qfFN is associated with an increasing risk of sPTB in this high-risk cohort. However, qfFN concentration is not predictive of response to either 17-P or vag-P in patients at high risk. In patients with a cervical cerclage, a qfFN 10 ng/mL appears to be associated with a failure of the cerclage to prevent sPTB.
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