An investigation into the Kumada cross coupling reaction was conducted by developing a reliable, efficient procedure for the Grignard reagent and its subsequent cross coupling reaction. Safe Mg metal activation as well as a moisture-free system was created by using MeMgCl reagent and improved the efficiency of the Grignard reaction. The established coupling reaction was successfully demonstrated at the multikilogram (50 kg) scale, and the coupling product was purified by using an agitated thin film evaporator (ATFE) technique.
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