Peritoneal keratin granuloma is a rare lesion included under granulomatous lesions of the peritoneum. It can be of infectious and non-infectious etiology. The lesion presents as a large intra-abdominal necrotic mass often misinterpreted clinically as a disseminated carcinoma. We report a case of peritoneal keratin granuloma in a 50-year-old male following peritonitis. Histomorphology revealed laminated keratin deposits with giant cell reaction. Follow-up data of this granuloma suggests that it has no prognostic significance.
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