Glycoproteins are an important class of proteins that play a significant role in many cellular events. In the present study, we analyze the influence of C-H...O interactions in relation to other environmental preferences in glycoproteins. CH...O interactions are now accepted as a genuine hydrogen bond. Main chain-main chain interactions are predominant. Proline residues stabilize strands by C-H...O interactions in glycoproteins. Majority of the C-H...O interacting residues were conserved and had one or more stabilization centers. CH...O interactions might be responsible for the global conformational stability, since long-range CH...O contacts were predominant. The results presented in this study might be useful for structural stability studies in glycoproteins.
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