Efficient catalytic one-step synthesis of substituted quinoline derivatives using newly synthesized Ru(II) half-sandwich complexes of the type [Ru(η 6 -pcymene)Cl(L)] (L = pyrrole-2-aldehydehydrazones) under mild conditions is described. The synthesized complexes exhibit excellent catalytic activity towards the coupling of 2-amino alcohol with functionalized ketones and secondary alcohols in the optimal conditions and afforded the corresponding quinoline derivatives. The synthetic pathway proceeds with high atom efficiency via a sequence of acceptorless dehydrogenation and condensation steps.The maximum isolated yield of the product obtained was up to 97% using 0.3 mol% of catalyst loading for 5 h. These findings significantly advance the scope of the synthesis of bioactive heterocyclic compounds from readily available starting materials.
New Ru(II)-TSC complexes of the type [RuH(TSC)(CO)(PPh 3 ) 2 ] (where TSC = monobasic bidentate anthracenealdehyde thiosemicarbazone ligands) were synthesized and characterized by means of elemental analysis, IR, UV À vis, and NMR spectral methods. Molecular structures of the complexes were determined by single crystal X-ray crystallography, which prove the coordination mode of the ligands and reveal the presence of a distorted octahedral geometry around the Ru ion. The synthesized complexes were developed as catalysts for selective oxidative cleavage of a wide range of alkenes as well as alkynes to the corresponding aldehydes/ diketones in acetonitrile/ water in the presence of NaIO 4 at room temperature. The maximum yield was obtained up to 99% using 0.5 mol% of catalyst loading without any over oxidation byproducts. The effect of substituents of the ligand, solvents, reaction temperature and catalyst loading on the catalytic activity of the complexes is also investigated.
The synthesis and structural characterisation of a new series of palladium(ii) benzhydrazone complexes have been described and the complexes were developed as efficient catalysts for Suzuki coupling reactions in aqueous medium.
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