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Serial plates are not reasonable in material saving and stress dispersion. To design orthopedic plates ideally and conveniently, this paper proposes a method to optimize plates through editing semantic parameters based on average bone model. Firstly, for the reasonable distribution of serial plates in number and size, an average bone model is created from the existing bones, among which each bone has a contribution to the average model. Secondly, a common orthopedic plate with semantic parameters is constructed on average bone model and it can be conveniently modified. Lastly, optimizing the thickness of the plate through finite element analysis and genetic algorithm to meet the stress condition and use as little material as possible. The simulation results indicate that the method can save material and disperse the stress of the plates so that it can effectively optimize the orthopedic plates.