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Introduction: Hyper-lucent lung syndrome or Swyer-James-Macleod syndrome is a rare, often an incidental finding, primarily showing unilateral hyper-lucency as a consequence of bronchiolitis obliterans. Often diagnosed in early childhood; though in some cases it may only be discovered in adulthood or on account of recurrent chest infections. Case Presentation: A patient presented to our outpatient center with complaints of shortness of breath with mild to moderate exertional dyspnea & exacerbations of symptoms classically associated with chronic obstructive pulmonary disease. Complaints have persisted for several years with waxing & waning intensity. There is a history of migraine, atrial fibrillation, hypothyroidism, and colon & breast cancer without recurrence. Computed tomography of the chest with intravenous contrast showed asymmetric emphysematous changes with marked hyperinflation & attenuated vasculatures confined to the middle lobe of the right lung. The patient was started on a combination of inhaled long-acting beta-agonists, corticosteroids & long-acting muscarinic antagonists and is almost asymptomatic. Conclusion: Geriatric patients are at increased risk of various age-related diseases, respiratory disorders being among them. Knowledge of this rare condition allows for its appropriate management as it often coexists with bronchiectasis & results in frequent respiratory infections, which may be preventable.

Poorly differentiated colonic carcinoma with rhabdoid features is a rarely described entity. Our knowledge regarding the molecular phenotype of the tumor is evolving. We herein report a similar tumor with rhabdoid differentiation identified in the splenic flexure, which on histological examination showed a poorly differentiated phenotype with epithelioid to spindled morphology, tumor giant cells, and rhabdoid differentiation. The tumor was mismatch repair-proficient, deficient of INI1/SMARCB1, KRAS mutated (A146×), BRAFV600E mutated (c.1799T > A), and NRAS wild-type, indicating serrated differentiation in the tumor. The patient died after 3.5 months post-surgery. INI1-deficient poorly differentiated carcinoma of the colon is a rare, aggressive colonic malignancy showing a serrated phenotype. Routine identification and subtyping are important keeping in mind the distinct tumor phenotype, resistance to conventional chemotherapy, and dismal prognosis.

Introduction: Lady Windermere Syndrome is the bronchiectasis of the right middle lobe or the lingula region due to Mycobacterium avium complex (MAC) infection. It was historically described in elderly Caucasian female patients who were immunocompetent but subsequently developed MAC infection, theoretically due to chronic cough suppression. The diagnosis is often difficult or missed because it is not usually considered a differential by radiologists and clinicians. Case Presentation: Here we describe a classic case of a 61-year-old female patient with Lady Windermere Syndrome who is also riddled with prominent kyphoscoliosis with supportive chest radiographs and CT findings. Conclusion: Lady Windermere syndrome is a significant yet frequently overlooked disease among older women who exhibit non-specific clinical symptoms. The majority of cases experience positive clinical outcomes within a period of three to six months when provided with timely pharmaceutical intervention. It is crucial to consider Lady Windermere syndrome as a potential differential diagnosis, particularly in regions where there are concerns about the presence of MAC bacilli in the soil and water.

Introduction: Lady Windermere Syndrome is the bronchiectasis of the right middle lobe or the lingula region due to Mycobacterium avium complex (MAC) infection. It was historically described in elderly Caucasian female patients who were immunocompetent but subsequently developed MAC infection, theoretically due to chronic cough suppression. The diagnosis is often di cult or missed because it is not usually considered a differential by radiologists and clinicians.Case Presentation: Here we describe a classic case of a 61-year-old female patient with Lady Windermere Syndrome who is also riddled with prominent kyphoscoliosis with supportive chest radiographs and CT ndings. Conclusion: LadyWindermere syndrome is a signi cant yet frequently overlooked disease among older women who exhibit non-speci c clinical symptoms. The majority of cases experience positive clinical outcomes within a period of three to six months when provided with timely pharmaceutical intervention. It is crucial to consider Lady Windermere syndrome as a potential differential diagnosis, particularly in regions where there are concerns about the presence of MAC bacilli in the soil and water.