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With a growing number of global challenges related to the environment, water, public health, and energy, there is an imminent need to teach chemistry in the context of its interconnectedness with other systems. Project-and problem-based learning are student-centered learning approaches which offer educators the opportunity to engage learners in solving complex real-world problems. By choosing a globally relevant project/problem and requiring students to utilize scientific methods to solve the problem, both problem-based learning and project-based learning are excellent strategies for educators to teach chemistry using a systems approach. This review summarizes key research studies which utilize project-and problem-based learning in the context of enabling learners to confront global problems and the wide applicability of these approaches to systems thinking.

Over the past decade, poly(3,4-ethylenedioxythiophene) (PEDOT) has been one of the widely investigated conjugated polymers due to its excellent electro-optical properties. The conventional synthesis of PEDOT/PSS involves oxidation of EDOT using strong oxidants in aqueous polystyrenesulfonate (SPS) solution. The low pH conditions and strong oxidants render this synthetic protocol unsuitable for use of PEDOT in applications such as biosensing. For the purpose of expanding the utility of PEDOT in these applications, it is important to develop a route that can provide the possibility of synthesizing PEDOT in the presence of the appropriate biological entities. Here we report the use of terthiophene as a radical mediator to synthesize PEDOT/PSS under milder pH conditions using soybean peroxidase (SBP). The oxidation potential of terthiophene is sufficiently low for initiation of the polymerization reaction catalyzed by SBP. The oxidized terthiophene helps the subsequent oxidation of EDOT, thus mediating the polymerization reaction. This novel approach involving the use of conjugated oligomers as redox mediators is generic and vastly expands the types of substrates (thiophenes, pyrroles) that can be polymerized using enzymatic methods and benign conditions.

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