The ortho-carbonylation of sulfonylarenes by non-hazardous aryl aldehydes as a carbonyl precursor was reported. In this method, the sulfonamide group serves as a directing group for CÀ H activation in the presence of a Pd catalyst under ligand-free conditions. The scope of this strategy has been extended to the onepot two-step synthesis of cyclic N-sulfonyl ketimines under mild reaction conditions. Our approach could be considered as an alternative by circumventing the use of highly reactive organolithium or Grignard reagents to access a wide range of biologically potent cyclic N-sulfonyl ketimines.
The prevalence of sulfones in natural products, pharmaceutically active molecules and functional materials draw immense attention for their synthesis. Here, we report a palladium-catalyzed protocol for synthesizing diaryl sulfones from the arenes through CÀ H activation. N-methoxy arenesulfonamide was exploited as a potential sulfonyl donor by the cleavage of SÀ N bond through a radical pathway. The present methodology has several advantages: a simple, readily available catalytic system; the use of a stable sulfonyl donor; a relatively moderate excess of arene coupling partner for an undirected CÀ H activation process, along with the tolerances of aryl bromides and iodides, which in turn permits further cross-coupling reactions to afford cross-coupled sulfones.
A novel Pd-catalyzed protocol desulfitative Heck type reaction of N-methoxy aryl sulfonamides with alkenes was reported. The cross-coupling reaction was performed successfully with a variety of olefins to obtainaryl alkenes....
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