Bromination of aliphatic hydrocarbons with NaOH/CBr4 under phase‐transfer conditions selectively gives the tertiary bromide. In the absence of a tertiary C–H bond in the molecule, a secondary bond will be activated (see reaction equation). This conceptionally new system for aliphatic C–H activation very likely relies on the initiation of single‐electron transfer followed by a radical substitution with unusually high regioselectivity.

Die Bromierung aliphatischer Verbindungen mit NaOH/CBr4 unter Phasentransferbedingungen liefert selektiv tertiäre Bromide. Fehlen tertiäre C‐H‐Bindungen im Molekül, so werden auch sekundäre aktiviert (siehe oben). Dieses konzeptionell neue Reaktionssystem zur C‐H‐Aktivierung wird sehr wahrscheinlich durch einen Einelektronentransfer eingeleitet und durch eine radikalische Substitution mit hoher Regioselektivität abgeschlossen.

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Usually, lipids are synthesized employing solution-phase organic synthesis techniques. Though successful, the purifications can be difficult to accomplish due to the amphiphilic nature of the molecules. Herein, we demonstrate the advantages of a solid-phase approach for preparing a variety of metal-chelating lipids. A number of saturated and polymerizable metal-chelating lipids were prepared using this methodology. This approach requires one chromatographic purification after cleaving the lipids from the solid support. We also demonstrate that the resulting polymerized liposomes (containing Eu3+) possess the appropriate luminescence properties for the qualitative and quantitative determination of proteins.