Three racemic butanolides, majorenolide (1), majorynolide (2), and majoranolide (3), with 18 known compounds, including ten butanolides, i.e., litsenolide A(2) (4), litsenolide B(2) (5), litsenolide C(1) (6), litsenolide C(2) (7), hamabiwalactone A (8), hamabiwalactone B (9), litseakolide A (10), litseakolide B (11), isoobtusilactone (12), and obtusilactone (13); one lignan, i.e., (+/-)-syringaresinol (14), two flavans, i.e., (+)-catechin (15), and (-)-epicatechin (16), one coumarin, i.e., scopoletin (17), and four steroids, i.e., a mixture of beta-sitosterol (18) and stigmasterol (19), and a mixture of beta-sitosteryl-3-O-beta-D-glucoside (20) and stigmasteryl-3-O-beta-D-glucoside (21) were isolated from the root of Lindera akoensis. The structures of the isolates were elucidated by in-depth spectroscopic analysis. Compounds 1-3 were previously assigned a delta-lactone structure, which was then revised to a gamma-lactone structure, based on 1D-NMR data. The cigar-HMBC technique was used to confirm the accuracy of the gamma-lactone structure, and the zero [alpha] (20)_D value of compounds 1-3 suggested that they were considerably racemized. Nine butanolides 1-3, 4-8, and 10 showed antimycobacterial activities against M. tuberculosis H(37)Rv, with MIC values of 15-50 microg/ml.
Six new butanolides, litseadioxanins A and B (1 and 2, resp.) bearing a 1,2‐dioxane moiety, litseatrinolides A and B (3 and 4, resp.), and litseakolides D1 and D2 (5 and 6, resp.), were isolated from the stem bark of Litsea akoensis, together with six known compounds. The structures of the new compounds were characterized by in‐depth NMR‐spectroscopic and mass‐spectrometric analyses. Butanolides 1–4, and a mixture of 6 and litsenolide E2, and litsenolide B1 were tested against human tumor cells, including MCF‐7 (human breast adenocarcinoma), NCI‐H460 (non‐small‐cell lung cancer), and SF‐268 (glioblastoma) cell lines. Among the tested compounds, litsenolide B1 exhibited marginal cytotoxic activity against MCF‐7, NCI‐H460, and SF‐268 cell lines in vitro.
Six new butanolides, litseadioxanins A and B (1 and 2, resp.) bearing a 1,2-dioxane moiety, litseatrinolides A and B (3 and 4, resp.), and litseakolides D 1 and D 2 (5 and 6, resp.), were isolated from the stem bark of Litsea akoensis, together with six known compounds. The structures of the new compounds were characterized by in-depth NMR-spectroscopic and mass-spectrometric analyses. Butanolides 1 -4, and a mixture of 6 and litsenolide E 2 , and litsenolide B 1 were tested against human tumor cells, including MCF-7 (human breast adenocarcinoma), NCI-H460 (non-small-cell lung cancer), and SF-268 (glioblastoma) cell lines. Among the tested compounds, litsenolide B 1 exhibited marginal cytotoxic activity against MCF-7, NCI-H460, and SF-268 cell lines in vitro.
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