After stratification, the hazard ratio in the group perfused with MMC compared to oxaliplatin was 0.17 (0.06 to 0.45), p < 0.001. Median disease-free survival was higher in the MMC group (37.1 vs 24 months), p ¼ 0.029. There was no difference in received adjuvant chemotherapy (p > 0.05). CONCLUSIONS: These data suggest that HIPEC perfusion with mitomycin C is associated with favorable survival outcomes compared to perfusion with oxaliplatin.
Gold nanoparticles and near infrared-absorbing light are each innocuous to tissue but when combined can destroy malignant tissue while leaving healthy tissue unharmed. This study investigated the feasibility of photothermal ablation therapy for esophageal adenocarcinoma using chitosan-coated gold/gold sulfide (CS-GGS) nanoparticles. A rat esophagoduodenal anastomosis model was used for the in vivo ablation study, and three human esophageal cell lines were used to study the response of cancer cells and benign cells to near infrared light after treatment with CS-GGS. The results indicate that both cancerous tissue and cancer cells took up more gold nanoparticles and were completely ablated after exposure to near infrared light. The benign tissue and noncancerous cells showed less uptake of these nanoparticles, and remained viable after exposure to near infrared light. CS-GGS nanoparticles could provide an optimal endoluminal therapeutic option for near infrared light ablation of esophageal cancer.
The cultivation of Lentinan edodes as a carrier for Se, low concentrations of sodium selenite solution were added directly to the medium to inorganic selenium be absorbed into the mushroom body, and selenium-enriched Lentinan edodes can be got. Using selenium-enriched mushrooms as raw material, it was preliminarily studied that patterns of occurrence of selenium and the contents of Selenoprotein and Se-polysaccharide in their fruiting bodies of mushrooms. Various extraction solvents were used to distill and separation Se-polysaccharide and Se-protein of the Lentinan edodes, and atomic absorption spectrometer was used to determine the selenium contents of all component parts. The results showed that Lentinan edodes have the ability of enrichment selenium and can transform inorganic selenium in the environment into organic selenium. The main group of Selenium is organic state. The selenium in protein occupied the total selenium 40.09%, In the four components of selenium protein, water-soluble proteins of selenium is main (21.65% of the total selenium).The selenium in polysaccharide occupied the total selenium 27.83%. Mass fraction of acid-soluble Se-polysaccharide than in water-soluble Se-polysaccharide and alkali-soluble Se-polysaccharide is higher (13.52% of total selenium). The main distributed form of the selenium is from the organic matter in the analyzed Lentinan edodes, the combined selenium in protein was higher.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.