In the field of drug delivery, a nebulizer is a device used to convert liquid drugs into tiny airborne droplets, such as aerosol or a mist form. These fine droplets are delivered to a patient’s lungs and airways and then spread throughout the body via blood vessels. Therefore, nebulization therapy is a highly-effective method compared with existing drug delivery methods. To enhance the curative influence of a drug, this study suggests the use of a new micro-porous mesh nebulizer consisting of a controllable palladium–nickel (Pd–Ni) membrane filter, piezoelectric element, and a cavity in the micro-pump. In this research, we optimize a biocompatible Pd–Ni membrane filter, such that it generated the smallest aerosol particles of various drugs. The pore size of the filter outlet is 4.2 μm ± 0.15 μm and the thickness of the Pd-Ni membrane filter is approximately 41.5 μm. In addition, the Pd–Ni membrane filter has good biocompatibility with normal cells. The result of a spray test with deionized (DI) water indicated that the size of a standard liquid droplet is 4.53 μm. The device has an electrical requirement, with a low power consumption of 2.5 W, and an optimal operation frequency of 98.5 kHz.
The medical diagnostic ultrasound market has grown steadily in recent years, thanks to the increasing popularity of minimally invasive surgery among patients and active investments in the medical ultrasound market. In addition, the diagnostic ultrasound market is expected to continue to grow in the global market, given the importance of ultrasound and ongoing technological developments. In the case of the gallbladder, cases of gallstones and nonalcoholic fatty liver disease, all of which can be diagnosed with abdominal ultrasound, the number of domestic patients continues to increase every year. The safety of abdominal ultrasound has also been improved due to the national health insurance expanding its coverage to include gallstones and diseases such as those of the liver and gallbladder. However, no standards by which the performance of abdominal ultrasound can be evaluated have been explicitly established. Therefore, we aimed to assess the performance of abdominal ultrasound using criteria such as sound output level, operating frequency accuracy, resolution, maximum display depth, distance accuracy, time accuracy, and blood flow velocity accuracy. These criteria were derived by investigating the principles of ultrasound and the characteristics and structure of transducers, as well as by analyzing the specifications of abdominal ultrasound set by the International Electrotechnical Commission (IEC) 60601-2-37.
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