date was used to represent the first transplant year methodology. A logistic regression of the survival rate, weighted by study variance, was performed including additive terms in the model for transplant type: Cord, Mixed, Sibling, Unrelated Donor (URD) and first transplant year. The model estimates were back-transformed to give probabilities of overall survival.
Results:The term for first transplant year was a significant predictor of survival in the model (p < 0.01 for 3 and 5 year data combined). There is an increase in survival with an increase in the year of first transplant. No significant differences were observed in outcomes between the donor types.
Summary/Conclusion:A relationship between survival and first year of transplant has been demonstrated, with survival improving over time. However, a great heterogeneity was observed between the trial groups, end points and data reporting. This makes any robust analysis of the data challenging. Standardisation of study endpoints would aid cross-trial comparison and therefore enable analysis of larger cohorts of patients.
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