We demonstrate an all-fiber channel-dropping filter comprising a 2 Â 2 side-polished fiber coupler with long coupling length and a narrow-band fiber Bragg grating. The side-polished fibers are fabricated on a silicon wafer acting as a polishing substrate while the alignment V-grooves are simultaneously prepared. Two polished fibers with an intracore Bragg grating between them are combined as a grating-frustrated coupler, and a low-loss channel-dropping filter was achieved with the spectral bandwidth less than 2 nm (25 dB), dropping efficiency greater than 98% and channel isolation greater than 25 dB. The filter can be manufactured through a fast and reliable fabrication process.
Rituximab is a monoclonal antibody used for the treatment of B-cell malignancies, including diffuse large B-cell lymphoma. Infusion-related hypersensitivity reactions to rituximab is well known, and delayed hypersensitivity reactions to rituximab are also reported. Desensitization is commonly used to prevent immediate hypersensitivity reactions, but recently there have been cases of successful desensitization therapy for delayed hypersensitivity reactions. A 66-year-old patient who underwent rituximab treatment for diffuse large B-cell lymphoma showed repeated rituximab-induced delayed hypersensitivity reactions with whole body rashes. Intravenous rapid desensitization was performed by using a 1-bottle, 11-step protocol for 6 cycles and thereafter hypersensitivity reaction did not recur. We herein reported a case of delayed hypersensitivity reaction caused by rituximab, which was successfully desensitized using our 11-step protocol.
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