INTRODUCTIONSomatostatin and its analogue octreotide in¯uence gastrointestinal motility and secretion. 1±3 Both inhibit gastric acid and pancreatic enzyme secretion, gallbladder contraction and delay intestinal transit. Recent studies indicate that octreotide affects visceral perception by increasing the threshold for symptoms during balloon distension. This has been demonstrated for rectal and colonic perception both in healthy subjects and patients with irritable bowel syndrome.3±6 Octreotide in¯uences perception through inhibition of the spinal afferent pathway. 4,6 Little is known about the effect of somatostatin on proximal gastric motor function and symptom perception. Only Mertz et al., 7 using the long-acting somatostatin analogue octreotide, found the gastric accommodation re¯ex to be reduced, resulting in a less compliant proximal stomach. Octreotide also had an inhibitory effect on the perception of fullness in response to low volume distensions. The aim of our study was to investigate the effect of native somatostatin during continuous intravenous infusion on the motor function of the proximal stomach and visceral perception during volume and pressure distensions. The function of the proximal stomach was measured with an electronic barostat. MATERIALS AND METHODS SubjectsSix healthy volunteers (four female, two male, mean age 23 years; range 19±27 years) participated in the study. None had a history of gastrointestinal symptoms, had previously undergone abdominal surgery or was using SUMMARY Background: Somatostatin affects gastrointestinal motility and secretion and visceral sensation, but little is known about its effects on the proximal stomach. Aim: To evaluate the effects of somatostatin on proximal gastric motor function and perception of symptoms. Methods: Six healthy subjects participated in two experiments performed in random order during continuous intravenous infusion of saline or somatostatin (250 lg/h). Proximal gastric motor function was evaluated using a barostat. We performed pressure and volume distensions and a barostat procedure (minimal
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