The aim of this article was to assess the oxygen-uptake efficiency slope (OUES) throughout the age span of 7 to 18 years. One hundred fourteen healthy children (58 boys and 56 girls) exercised on a treadmill by means of a modified Balke protocol. The OUES grew in a nonlinear pattern with age, and it appeared to be significantly higher in boys than in girls. There was a very strong correlation between OUES and VO2peak (r = .92), and there was a small difference between the values of OUES calculated for different exercise intensities. Stepwise-regression analysis outlined body surface area (BSA) and sex as main determinants of OUES. OUES is an objective measure of exercise capacity that does not require a maximal effort but is considerably dependent on anthropometric variables and necessitates the generation of appropriate reference values.
INTRODUCTION: A diagnosis of lung function impairment in childhood is highly dependent on the respective reference values. Population differences in the pulmonary function of children have been frequently reported.
The AIM of this study was to derive normal spirometric reference values for Bulgarian children and adolescents and to compare these results with other data set including our own reference equations developed 20 years ago.
MATERIAL AND METHODS: Forced vital capacity (FVC), forced expiratory volume in 1 s (FEV1), and parameters of maximum expiratory flow-volume curves were measured in 671 healthy Bulgarian school children (339 males and 332 females) aged 7-18 years. Multiple linear regression analysis was performed for each spirometric parameter against age, height, weight, chest circumferences and fat free mass in both sexes.
RESULTS: Excluding ratios, all measured spirometric parameters increased nonlinearly with age and height, and were significantly higher in boys than girls in adolescence.
Height (H) explained the maximum variance for spirometric parameters and the best-fit regression equation relating functional parameters and body height was a power function (Y = a.Hb). FVC and FEV1 showed close correlations with height (r2 between 0.85 and 0.92), whereas the coefficients of determination for the flows were less close (r2 from 0.85 for PEF to 0.67 for MEF25%; always higher in boys).
CONCLUSIONS: The developed prediction equations can be used in clinical practice. In comparison with reference equations based on European or USA populations, regional reference values are biologically more suitable for the interpretation of spirometric data.
Results Correlation with ACQ-5 was obtained for the Hildebrandt index (r=0,45 p=0,0003), the respiratory rate (r=-0,27, p=0,032) and the relative pulse index (r=0.40, p=0,0012). The association of Kerdo index with ACT-C test values (r=-0,32, p=0,045) was established. In the group of patients with no BA control the Hildebrandt index was statistically significantly higher than in patients with control of the disease. In children with uncontrolled asthma it was 5,23 ±0,25 units that exceeds normal values and may reflect a mismatch in the work of cardiovascular and respiratory systems. Conclusion The interrelation of changes of vegetative regulation and the level of control of bronchial asthma in children is established, as well as the mismatch of the functioning of the cardiovascular and respiratory systems in children with uncontrolled asthma.
Abstracts
A164ADC 2019;104(Suppl 3):A1-A428
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