Cue competition is one of the most studied phenomena in associative learning. However, a theoretical disagreement has long stood over whether it reflects a learning or performance deficit. The comparator hypothesis, a model of expression of Pavlovian associations, posits that learning is not subject to competition but that performance reflects a complex interaction of encoded associative strengths. That is, subjects respond to a cue to the degree that it signals a change in the likelihood or magnitude of reinforcement relative to that in the cue's absence. Initially, this performance-focused view was supported by studies showing that posttraining revaluation of a competing cue often influences responding to the target cue. However, recently developed learning-focused accounts of retrospective revaluation have revitalized the debate concerning cue competition. Further complicating the picture are phenomena of cue facilitation, which have been addressed less frequently than cue competition by formal models of conditioning of either class. The authors present a formalization and extension of the comparator hypothesis, which results in sharpened differentiation between it and the new learning-focused models.

The present study compared four prominent models of delay discounting: a one-parameter exponential decay, a one-parameter hyperbola (Mazur, 1987), a two-parameter hyperboloid in which the denominator is raised to a power (Green and Myerson, 2004), and a two-parameter hyperbola in which delay is raised to a power (Rachlin, 2006). Sixty-four college undergraduates made choices between hypothetical monetary rewards, one immediate and one delayed, and the fit of the four models to their data was assessed. All four equations accounted for a large proportion of the variance at both the group and the individual levels, but the exponents of both two-parameter models were significantly less than 1.0 at the group level, and frequently so at the individual level. Taken together, these results strongly suggest that more than one parameter is needed to accurately describe delay discounting by humans. Notably, both the Rachlin and the Green and Myerson models accounted for more than 99% of the variance at the group level and for 96% of the variance in the median individual. Because both models provide such good descriptions of the data, model selection will need to be based on other grounds.

Selective, nonpeptide antagonists for tachykinin receptors first became available ten years ago. Of the three known tachykinin receptors, drug development has focused most intensively on the substance P-preferring receptor, neurokinin(1) (NK(1)). Although originally studied as potential analgesic compounds, recent evidence suggests that NK(1) receptor antagonists may possess antidepressant and anxiolytic properties. If confirmed by further controlled clinical studies, this will represent a mechanism of action distinct from all existing antidepressant agents. As reviewed in this chapter, the existing preclinical and clinical literature is suggestive of, but not conclusive, concerning a role of substance P and NK(1) receptors in the pathophysiology of depression and/or anxiety disorders. The ongoing clinical trials with NK(1) receptor antagonists have served as an impetus for much needed, basic research in this field.

Four conditioned lick suppression experiments with rats examined the effect of trial spacing on cue interaction. Experiments 1 and 2 found overshadowing to be eliminated with massed compound stimulus-outcome pairings and the usual trial spacing effect to be reversed with compound acquisition trials. Experiment 3 found that whether acquisition compound-outcome pairings were massed or spaced determined the effect of posttraining extinction treatment. Extinction of the overshadowing cue reduced responding following massed training and increased responding following spaced training. Extinction of the context decreased responding following massed training. Experiment 4 found the conditioning and devaluation results to be associative and stimulus specific. These results are in accord with the extended comparator hypothesis (J. C. Denniston, H. I. Savastano, & R. R. Miller, 2001).

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