The aim of this work is the protection of piroxicam from photodegradation by forming inclusion complex with 2-hydroxypropyl-β-cyclodextrin. Piroxicam:2-hydroxypropyl-βcyclodextrin molecular inclusion complex was prepared by coprecipitation method with 1:1 molar ratio. Structural characterization of the complex, the corresponding physical mixture and complexing agents of piroxicam and 2-hydroxypropyl-β-cyclodextrin was carried out by X-ray diffraction (XRD), proton nuclear magnetic resonance (1 H-NMR) and Fourier transform infrared spectroscopy (FTIR). Photosensitivity to daylight of piroxicam and piroxicam:2-hydroxypropyl-β-cyclodextrin inclusion complex was investigated by FTIR. The investigations show that higher photostability of piroxicam was achieved in the complex than in non-complexed piroxicam.
This paper presents the procedure for the synthesis of hydrogels based on Nisopropylacrylamide (NIPAM) and 2-hydroxypropyl methacrylate (HPMet) using dioxan as a solvent. Hydrogels were obtained by radical polymerization using different contents of ethylene glycol dimethacrylate as a cross-linker and benzoyl peroxide as the initiator. In the FTIR spectra of poly(N-isopropylacrylamide-co-2-hydroxypropylmethacrylate) (p(NIPAM-HPMet)) xerogel, new absorption bands are present and there are no specific bands characteristic of a monomer NIPAM, which indicates that copolymerization was performed. SEM micrographs show porous surfaces of xerogels. The aim of this work was the investigation of the swelling behavior for all synthesized hydrogels with different cross-linker content at the temperature from 20 to 40 °C. The sample of p(NIPAM-HPMet) with the lowest cross-linker content reached the highest swelling degree at 20 °C (α=20.23). The degree of swelling decreased with increasing the cross-linker content and temperature, so the samples with highest cross-linker content at 40 °C reached the swelling degree of 2.05.
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