There was no significant increase in overall psychiatric disorders, other than sleep disorders and disturbances, in varenicline-treated subjects in this sample of smokers without current psychiatric disorders. Ongoing studies are testing the use of varenicline in psychiatric patients.

Sexual desire discrepancies and the associations between desire discrepancies and relationship adjustment (i.e., sexual and relationship satisfaction) in heterosexual dating couples (N = 72) were examined Desire discrepancies were assessed via two methods: (1) a couple-based index created using both individuals' reports of sexual desire and (2) an individual-based index using each person's own subjective perception of a desire discrepancy within the couple. Both indices were associated with women's adjustment, whereas only individual perceptions of discrepancies were associated with men's adjustment. The association between desire discrepancies and general relationship satisfaction was fully mediated by level of sexual satisfaction for both men and women. Women whose sexual desire level was lower than their partners' endorsed lower levels of relationship adjustment relative to women whose desire was either greater than or similar to their partners'. Implications for the assessment of sexual desire differences in couples are discussed.

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Home advantage has been examined across different sports. Pollard provided evidence of this phenomenon in association football (soccer). This present study further considers the prevalence in the English Football Premiership, a division created from the former Football Association First Division in 1992. Archived data were obtained for the First Division seasons 1984--5 to 1991--2 from the Football Statistics Archive and for the English Football Premiership (1992--3 to 2002--3). Chi square analysis confirmed home advantage from season to season since 1984 (p<.05). Analysis of variance compared Pollard's findings and data for the English Football Premiership (1992--2003), as well as the intervening period (1984--92). Home advantage was significantly lower in these more recent periods. Possible factors contributing to the apparent decline in home advantage were highlighted.

BackgroundSub-optimal parenting is a common risk factor for a wide range of negative health, social and educational outcomes. Most parenting programmes have been developed in the USA in the context of delinquency prevention for targeted or indicated groups and the main theoretical underpinning for these programmes is behaviour management. The Family Links Nurturing Programme (FLNP) focuses on family relationships as well as behaviour management and is offered on a universal basis. As a result it may be better placed to improve health and educational outcomes. Developed in the UK voluntary sector, FLNP is popular with practitioners, has impressed policy makers throughout the UK, has been found to be effective in before/after and qualitative studies, but lacks a randomised controlled trial (RCT) evidence base.Methods/DesignA multi-centre, investigator blind, randomised controlled trial of the FLNP with a target sample of 288 south Wales families who have a child aged 2-4 yrs living in or near to Flying Start/Sure Start areas. Changes in parenting, parent child relations and parent and child wellbeing are assessed with validated measures immediately and at 6 months post intervention. Economic components include cost consequences and cost utility analyses based on parental ranking of states of quality of life. Attendance and completion rates and fidelity to the FLNP course delivery are assessed. A nested qualitative study will assess reasons for participation and non-participation and the perceived value of the programme to families. By the end of May 2010, 287 families have been recruited into the trial across four areas of south Wales. Recruitment has not met the planned timescales with barriers including professional anxiety about families entering the control arm of the trial, family concern about video and audio recording, programme facilitator concern about the recording of FLNP sessions for fidelity purposes and delays due to the new UK research governance procedures.DiscussionWhilst there are strong theoretical arguments to support universal provision of parenting programmes, few universal programmes have been subjected to randomised controlled trials. In this paper we describe a RCT protocol with quantitative and qualitative outcome measures and an economic evaluation designed to provide clear evidence with regard to effectiveness and costs. We describe challenges implementing the protocol and how we are addressing these.Trial RegistrationCurrent Controlled Trials ISRCTN13919732

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