SIVARAJAN M, AMORY DW, McKENZlE SM. Regional blood flows during induced hypotension produced by nitroprusside or trimethaphan in the rhesus monkey. Anesth Analg 1985;64:759-66. 111 monkeys anesthetized with 7070 nitrous oxide and 0.5% inspired halothane in oxygen, uie measured changes in systemic herriadynamics and regional blood pows produced by nitroprusside and trimethaphan. Regional blood flow measurements were made using the radioactive microsphere rechnique. Control measurements were made before infusion of nitroprusside and trirnethaphan into each animal in sequence in amounts adequate to reduce mean arterial pressure to approximately 55 2 5 mm Hg. Measurements were made during each drug infusion after a stable period of bypotension lasting at least 30 rnin. During nitroprusside infusion, cerebral blood flow remained unchanged, but myocardial blood flow increased significantly. Houmer, pressure-rate product, an indirect nieasure of tnyocardial oxygtii consumption, was unchanged, implying that tnyocardial blood f l~z c~ exceeded myocardial oxygen requirement. Duritig trimethaphan infusion, cerebral blood flou, decreased, dthou'yh cerebral metabolic rate for oxygen uias undmnged due to increased oxygen extraction hy the brain. Triniethapkan also produced a decrease in myocardial blood flow that was in proporfion to the decrease in myocardial oxygen requiremetif as indicated by pressure-rate product. Neither drug produced changes in renal or total hepatic blood flows. W e concltrdtp that brain oxygen reserve is decreased during hypotension induced by trimethaphan. Blood flous to other organs are not significantly impaired in monkeys dtirinx hypotension to a mean arterial pressure of approximately 55 mni Hs induced b.y either nitroprusside or trimathayhati.
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