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A paired comparison of the efficacy of a topically applied fluoridated corticosteroid, 0.2% fluocinolone acetonide in a cream base (Synalar-HP®, Syntex) and the base alone was carried out in 28 patients with alopecia areata and alopecia totalis. A satisfactory to excellent therapeutic response was obtained in 17/28 patients (61%), with the corticosteroid cream treatment. The patient’s age and the duration of the alopecia appeared to be important factors in the outcome. Although relapses were encountered in 11/17 patients (63%) during the course of treatment or within 3 months after treatment was discontinued, 12/17 (71%) of those who responded did retain sufficient regrowth for the result to be considered satisfactory. The only troublesome complication was the development of a localized acneform eruption in 5/28 patients (18%) between the ages of 15 and 25 years. None of the patients developed clinical evidence of systemic absorption.

Dermatologic surgeons in the United States have contributed significantly to the history of reconstructive and cosmetic surgery. Dermatologic surgeons have been leaders in advancing this field and are poised to continue in the future.

diabeteh insipidus: in vivo and in vitro studies. J Clin Invest sensitive adenyl cyclase. Life ki [I] 9:765 770. 1970 51:IOXI 1091. 1972 18. Demers RG. Heninger GR: Sodium intake and lithium treatment 16. Harris CA. Jenner FA: The inhibition of the action of vasopressin in mania. Am J Psychiatry 128: 100 104. 197 1 by lithium ions (abstract). J Physiol (London) 200:59. 1969 19. Thomson T, Schou M: Renal lithium excretion in man. Am J Phys-17. Dousa T. Hcrchter 0: The erect of NaCl and LiCl on vasopressiniol 2 15:X23-827. 1968

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